STA-9090(Ganetespib) in Patients With Unresectable Stage III or Stage IV Melanoma

Melanoma Clinical Trial

Official title:

A Phase II Study of the HSP90 Inhibitor STA-9090 in Patients With Unresectable Stage III or Stage IV Melanoma Who Received Prior Tyrosine Kinase Inhibitor Treatment

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT01551693
• Other study ID #: 11-039
• Status: Active, not recruiting
• Phase: Phase 2
• First received: April 29, 2011
• Last updated: November 16, 2016
• Start date: September 2011
• Est. completion date: January 2017

Study information

• Verified date: November 2016
• Source: Dana-Farber Cancer Institute
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

STA9090 is a drug which inactivates or blocks the work of a protein called Heat Shock Protein 90 or HSP90. HSP90 is a protein that helps some molecules inside your cells to have the right shape. By stopping HSP90's activity, those molecules never get to have the right structure of be functional and they are destroyed. The investigators believe that if they stop the activity of HSP90, the rapidly dividing cells that are in your tumor(s) may slow down. In this research study the investigators are looking to see how well STA9090 works in stopping the spread of your melanoma.

Description:

STA-9090 will be given intravenously over 1 hour. Treatment will be given in cycles which last 28 days (4 weeks). Study drug will be given once a week for the first 3 weeks (days 1, 8 and 15) and not during the last week.

Subjects will receive a clinical exam, ECG (before and after study drug) and blood tests on days when they receive the study drug. In Cycle 1, subjects will have a biopsy and blood samples taken on Day 2.

20 to 30 days after the last study treatment, subjects will have a clinical exam, ECG, blood tests, pregnancy test (if applicable), tumor assessment by CT, urine sample and possible biopsy.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 3
• Est. completion date: January 2017
• Est. primary completion date: May 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

• Histologically confirmed unresectable stage III or stage IV melanoma

• Treatment of unresectable stage III or stage IV melanoma with a tyrosine kinase inhibitor within prior 4 months. Sorafenib for purposes of eligibility will not be considered acceptable prior therapy

• Sufficient tumor available to determine if expresses wild-type or mutated BRAF if result not already known. The presence or absence of BRAF mutation needs to be determined at BWH, MGH, BIDMC, by Drs. Christopher Corless and Michael Heinrich at Cancer Pathology Shared Resource Oregon Health & Science University, or in context of eligibility assessment after signing consent to a previous clinical trial

• Sufficient tumor available to determine if expresses a mutation KIT

• Agreement to allow tumor to be evaluated for mutations in KIT and BRAF

• ECOG performance status = 1

• Life expectancy of = 6 months

• Age = 18 years

• WBC = 3 x 103/ul

• ANC = 1,500/ul

• Platelets = 100 x 103/ul

• Hemoglobin = 9 gm/dl

• Serum creatinine = 1.5 x ULN

• Calculated creatinine clearance = 60 mL/min

• AST = 2.5 x ULN; -OR- AST = 5 x ULN in the presence of known liver metastases

• ALT = 2.5 x ULN; -OR- ALT = 5 x ULN in the presence of known liver metastases

• Total bilirubin = 1.5 x ULN

• Potassium within normal range or correctable with supplements

• Magnesium within normal range or correctable with supplements

• Corrected serum calcium within normal range, or correctable with supplements

• Not pregnant or breastfeeding. Female subjects of childbearing age must have a negative serumpregnancy test at study entry

• Women of childbearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation and for 6 months following last study drug administration

• Agreement to provide blood samples for pharmacodynamic studies utilizing Peripheral Blood Mononuclear Cells (PMBCs) as outlined in protocol

• At least one site of measurable disease as defined by at least 1 cm in greatest dimension. This site must be different from the sites to be used for biopsy. No prior radiation therapy or directed ablation to the site of measureable disease

• Able to understand and willing to sign a written informed consent document

• Willing and able to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures

• No chemotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to study entry

• No radiotherapy within 4 weeks prior to study entry

• Subject has recovered from adverse events due to agents administered more than 4 weeks earlier

• No tyrosine kinase inhibitor within 14 days prior to study entry

• No major surgery within 4 weeks prior to first dose of STA-9090

• No minor surgery within 7 days of first dose of STA-9090

• No history of or current coronary artery disease, myocardial infarction, angina pectoris, angioplasty

• or coronary bypass surgery

• No current treatment with the following antiarrythmic drugs: flecainide, moricizine or propafenone

• No NYHA class II/III/IV congestive heart failure with a history of dyspnea, orthopnea, or edema that requires current treatment with angiotensin convering enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, or diuretics

• No current or prior radiation to the left hemithorax

• No embolization procedure or ablation procedure to treat tumor within 4 weeks of first dose of STA- 9090

• Not receiving any other investigational agents

• No poor venous access for study drug administration unless subject can use silicone based catheters

• No history of brain metastases or of leptomeningeal involvement

• No history of severe allergic reactions or hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to STA-9090 (e.g. olyethylene glycol [PEG] 300 or Polysorbate 80)

• Baseline QTc = 470 msec

• No previous history of QT prolongation while taking other medications

• Ventricular ejection fraction (EF) > 55%

• No treatment with chronic immunosuppressants

• No melanoma of ocular primary

• No prior treatment with hsp90 inhibitor

• No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, ventricular arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

• No other medications, or severe acute/chronic medical of psychiatric conditions or laboratory abnormality that may increase the risk associated with the study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the subject inappropriate for entry into the study

• No history of a different malignancy except for the following circumstances. Individuals with a history of other malignancies are eligible if they have been disease-free for at least 5 years and are deemed by the investigator to be at low risk for recurrence of that malignancy. Individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin

• No HIV-positive subject on combination antiretroviral therapy

• No more than 3 prior systemic therapies for unresectable stage III or stage IV melanoma

• No concomitant use of medications associated with a high incidence of QT prolongation as outlined

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Melanoma

Intervention

Drug:
• STA-9090
200 mg/m^2 IV over 1 hours +/- 15 min, on days 1, 8 15 of 28 day cycle

Locations

Country	Name	City	State
United States	Dana-Farber Cancer Institute	Boston	Massachusetts

Sponsors (2)

Lead Sponsor	Collaborator
Dana-Farber Cancer Institute	Synta Pharmaceuticals Corp.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Survival and disease free progression	To determine the proportion of patients alive, free of disease progression, and still taking STA-9090 at 6 months in patients with stage III unresectable or stage IV melanoma in each BRAF cohort	2 years	No
Secondary	Overall response	To assess best overall response rate and six month response rate of STA-9090 in patiens with stage III unresectable or stage IV melanoma in each BRAF cohort.	2 years	No
Secondary	One-year overall survival	To evaluate the rates of one-year overall survival and progression-free survival in each cohort.	2 years	No
Secondary	Safety and tolerability	To determine safety and tolerability of STA-9090 in subjects with melanoma in each BRAF cohort, evaluating disease progression by tumor measurement and the review of applicable adverse events.	2 years	Yes
Secondary	6 month response rate	To assess six month response rate of STA-9090 in patiens with stage III unresectable or stage IV melanoma in each BRAF cohort.	2 years	No