Melanoma Clinical Trial
Official title:
Neoadjuvant Anti-CTLA4 Blockade With Ipilimumab in Patients With AJCC Stage IIIB-C (Tx,1-4, N1b,2b, 2c, 3, M0) Melanoma: Immunogenicity And Biomarker Analysis
Ipilimumab is a manufactured monoclonal antibody, much like the antibodies usually made by
the human body to fight off infection; however it is not known why the human body does not
"fight off" a cancerous tumor. The idea behind developing this experimental drug is to
stimulate the immune system to make antibodies to kill cancer cells. This research study is
considered "experimental" because it has not received approval from the Food and Drug
Administration (FDA) for the treatment of this type of cancer.
This monoclonal antibody has been specifically made to block Cytotoxic T Lymphocyte Antigen 4
(CTLA4), which is a protein found on cells of the immune system. CTLA4 seems to slow down the
immune response, so blocking it with an anti-CTLA4 antibody may make the immune response more
active. The purpose of this study is to see if Ipilimumab affects the response of the
patient's immune system toward their cancer.
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