Melanoma Clinical Trial
Official title:
(Inhibition of NF-kB Signaling in Melanoma Therapy) A Phase I/II Clinical Trial of PS-341, a Proteasome Inhibitor, in Combination With an Extended Continuous Oral Schedule of Temozolomide in Patients With Advanced Refractory Solid Tumors With the Phase II Component Only in Patients With Melanoma
RATIONALE: Drugs used in chemotherapy, temozolomide, work in different ways to stop the
growth of tumor cells, either by killing the cells or stopping them from dividing.
Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for
cell growth. Giving temozolomide together with bortezomib may kill more tumor cells.
PURPOSE: To determine the best dose of bortezomib and temozolomide and to see how well they
work in treating patients with advanced refractory solid tumors or melanoma.
n/a
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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