Melanoma Clinical Trial
Official title:
Vaccination of Patients With Stage III or IV Malignant Melanoma With Melanoma Antigen Peptides [Melan-A/Mart-1 Analog (ELA), NY-ESO-1b(A) Analog and MAGE-A10] and Montanide Adjuvant
The purpose of this study is to determine whether vaccination with melanoma antigen peptides [Melan-A/Mart-1 (both EAA and ELA), NY-ESO-1b analog, Long NY-ESO-1 LP and MAGE-A10] and Montanide, CpG adjuvants and low dose rIL-2 can induce an immune response in melanoma patients and to assess the safety of this vaccination.
Current peptide vaccines suffer from low efficiency, since they induce only weak immune
activation. We have recently confirmed that in humans the immune response was readily
detectable in local lymph nodes while no or only weak activation could be identified in
circulating lymphocytes. Increased doses of antigen and adjuvant allow a better extension
from local to systemic immune responses.
- Group 1 : vaccination with Melan-A analog (ELA) peptide + Montanide
- Group 2 : vaccination with Melan-A analog (ELA), NY-ESO-1b analog and MAGE-A10 peptides
+ Montanide
- Group 3: vaccination with Melan-A analog (both EAA and ELA), Mage-A10, NY-ESO-1
peptides+ Montanide + CpG adjuvant
- Group 4: vaccination with Melan-A (ELA), Mage-A10,long NY-ESO-1LP peptides + Montanide +
CpG
- Group 5: vaccination with Melan-A (both EAA and ELA), Mage-A10, long NY-ESO-1 LP
peptides + Montanide + CpG + low dose rIL-2
;
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