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Intrathecal Double Checkpoint Inhibition — IT-IO  

Melanoma Stage IV Clinical Trial

Official title:
Intrathecal Administration of Anti-PD1/Anti-CTLA-4 in Combination With Systemic Combination of Anti-PD1/Anti-CTLA-4 in Patients With NSCLC Without Oncogenic Driver Mutation or Melanoma and Newly Diagnosed Leptomeningeal Metastasis: a Multicentric Phase I Study

Clinical Trial Summary

The objective of the present study is to determine the feasibility and to explore anti-tumor activity of intrathecal double immune checkpoint inhibition for patients with newly diagnosed leptomeningeal metastases from non-small cell lung cancer without driver mutation or melanoma.

Clinical Trial Description

The treatment regimen within the IT-IO study consists of intrathecal administration of nivolumab/ipilimumab in combination with systemic combined nivolumab/ipilimumab. The scheme of administration of systemic nivolumab/ipilimumab corresponds to the current standard of care for non-small cell lung cancer and for melanoma patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05598853
Study type Interventional
Source University of Zurich
Contact Emilie Le Rhun
Phone +41 44 255 55 00
Email IT-IO@usz.ch
Status Recruiting
Phase Phase 1
Start date November 25, 2022
Completion date April 2025
View Details
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