Adaptive BRAF-MEK Inhibitor Therapy for Advanced BRAF Mutant Melanoma

Status Recruiting

Clinical Trial Summary

This pilot early phase I trial studies how well encorafenib, binimetinib, and nivolumab work in treating patients with BRAF mutant stage IIIC-IV melanoma. Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with nivolumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving encorafenib, binimetinib, and nivolumab may kill more tumor cells.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03543969
Study type	Interventional
Source	H. Lee Moffitt Cancer Center and Research Institute
Contact
Status	Recruiting
Phase	Early Phase 1
Start date	June 14, 2018
Completion date	July 2028

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See also
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