Melanoma (Skin) Clinical Trial
Official title:
Immune Counter-Regulation in Melanoma Patients Vaccinated With GM-CSF
RATIONALE: Studying samples of blood from patients treated with sargramostim in the
laboratory may help doctors learn more about the effects of sargramostim on cells. It may
also help doctors understand how patients respond to treatment.
PURPOSE: This research trial studies biomarkers in blood samples from patients with stage IV
melanoma previously treated with sargramostim.
OBJECTIVES:
Primary
- To correlate circulating myeloid-derived suppressor cells (MDSC) and Treg frequencies
with clinical outcome.
Secondary
- To correlate circulating anti-sargramostim (GM-CSF) antibody levels with clinical
outcome.
OUTLINE: Archived peripheral blood mononuclear cells and serum samples are analyzed for
circulating myeloid-derived suppressor cells, Treg (CD3+/CD4+/CD25hi/FOXP3+) frequency, and
anti-sargramostim (anti-GM-CSF) antibody levels by flow cytometry and anti-GM-CSF
neutralizing antibody assay.
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