Melanoma (Skin) Clinical Trial
Official title:
Phase II Evaluation of RFS 2000 (9-Nitro-Camptothecin, 9NC) in Metastatic Melanoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of nitrocamptothecin in treating patients
who have metastatic melanoma.
OBJECTIVES: I. Assess the efficacy and toxicity of nitrocamptothecin in patients with
metastatic melanoma.
OUTLINE: Patients are stratified according to disease (choroidal vs nonchoroidal). Patients
receive oral nitrocamptothecin daily on days 1-5. Treatment continues weekly for at least 8
weeks (2 courses) in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 28-74 patients (14-37 per stratum) will be accrued for this
study.
;
Primary Purpose: Treatment
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