Medication Adherence Clinical Trial
— PACTOfficial title:
Improving Adherence to Pharmacological Treatment
The overall goal of this study was to implement and evaluate the effects of a systems-based and pharmacist-mediated program designed to improve adherence for patients with known coronary heart disease (CHD) to lipid-lowering pharmacologic therapy and of their physicians/nurse practitioners to the National Cholesterol Education Program Guidelines.
Status | Completed |
Enrollment | 689 |
Est. completion date | May 2005 |
Est. primary completion date | May 2005 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 30 Years to 85 Years |
Eligibility |
Inclusion Criteria: - was between 30 and 85 years of age; - had known CHD, defined as the presence of at least one coronary lesion at coronary angiography of >50%. Exclusion Criteria: - was unable or unwilling to give informed consent; - had a history of intolerance to two or more statin drugs; - planned to move out of the area within one year of recruitment; - had a poor prognosis such that life expectancy was thought to be <5 years; - had a psychiatric illness which limited ability to participate; or - had no telephone. |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
United States | UMass Memorial Medical Center | Worcester | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
University of Massachusetts, Worcester | National Institutes of Health (NIH) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The primary outcome evaluated is the percentage of patients with a serum low-density lipoprotein cholesterol (LDL-C) level <70 mg/dl. | One year | No | |
Secondary | Proportion of prescribed lipid-lowering medication taken by patients as measured by a continuous multiple-interval (CMA) measure of medication availability based on pharmacy records. | One year | No |
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