Mechanical Ventilation Clinical Trial
Official title:
Electrical Impedance Tomography Guided Assessment of Optimum PEEP Levels During Mechanical Ventilation in Lateral Decubitus Position
Goal of this study is to determine optimal PEEP levels for patients undergoing surgery in
lateral decubitus position. Patients will be randomized into 3 groups - PEEP 0, 5 and 10
mbar. Endotracheal anesthesia will be conducted with propofol, fentanyl, rocuronium and
sevoflurane/O2/air gas mixture.
Patients with preexisting lung disease, organ transplants and disseminated malignant disease
will be excluded.
Demographic data - age, weight, height, ASA status, smoking history will be recorded. EIT
measured parameters - tidal variation ratio of nondependent and dependent lung, regional
end-tidal and end-expiratory lung impedances as well as horizontal and vertical centers of
ventilation will be recorded and calculated at 3 time points - before anesthesia induction, 5
minutes after lateral positioning of the patient and 90 minutes after lateral positioning.
ABGs will be sampled to calculate aA gradient and Horovitz quotient at those time points as
well as measured hemodynamic parameters (HR, BP, CI, SVI).
Primary endpoints for the study are nondependent/dependent tidal variation ratios measured at
predefined time points and changes in ABGs. Secondary endpoints are number of postoperative
pulmonary complications (defined as new onset of pneumonia during 28 days of followup),
length of hospital stay and changes in hemodynamic parameters.
n/a
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