Mechanical Ventilation in Multiple Fracture Ribs

Mechanical Ventilation Clinical Trial

Official title: Biphasic Intermittent Positive Airway Pressure (BIPAP) Versus Airway Pressure Release Ventilation (APRV) in Patients With Multiple Fracture Ribs

Status Recruiting

Clinical Trial Summary

Chest trauma is the most common injury in the emergency trauma and rib fractures is the most common trauma in chest trauma. Severe rib fractures can cause paradoxical respiration and mediastinal swing, which has large effects on respiratory and circulatory system, result in acute respiratory distress syndrome. Mechanical ventilation can significantly improve the hypoxemia of the patients, correct paradoxical respiration, and treat the pulmonary atelectasis

Clinical Trial Description

To compare between Biphasic Intermittent Positive Airway Pressure (BIPAP) ventilation and Airway Pressure Release Ventilation (APRV) mode in patients with multiple fracture ribs as regard:

• Resting Energy Expenditure

• Oxygenation

• Stability of Physiological Status as cardiovascular activity

• cardiac output

• arterial blood gas measurement including [ blood PH, arterial oxygen tension, arterial carbon dioxide tension, bicarbonate level and base deficit]

• lung and chest compliance

• Length of intensive care unit stay.

• The ICU mortality rate.

• The development of major complications as nosocomial infection (hospital acquired pneumonia and ventilator associated pneumonia), major atelectasis and pneumothorax. ;

Related Conditions & MeSH terms

• Mechanical Ventilation
• Rib Fractures

• NCT number: NCT03314701
• Study type: Interventional
• Source: Assiut University
• Status: Recruiting
• Phase: N/A
• Start date: October 25, 2017
• Completion date: December 2018