Endotracheal Tube With Polyurethane Cuff and Subglottic Secretion Drainage — A/N  

Mechanical Ventilation Clinical Trial

Official title: Influence of an Endotracheal Tube With Polyurethane Cuff and Subglottic Secretion Drainage on Ventilator-Associated Pneumonia

Status Completed

Clinical Trial Summary

Patients mechanically ventilated using an endotracheal tube with a subglottic secretion drainage lumen and a polyurethane cuff may develop lower ventilator-associated pneumonia than using a conventional endotracheal tube

Clinical Trial Description

Subglottic secretions accumulated above the endotracheal cuff may progress, descending along the channels within folds of the cuff wall, to the lower respiratory tract causing VAP. Subglottic secretion drainage (SSD) appears to be effective in preventing VAP, primarily by reducing early-onset pneumonia; but it may not prevent late-onset pneumonia. We set out the hypothesis that using an endotracheal tube incorporating, besides of a subglottic secretion drainage lumen, a polyurethane cuff (which reduces channel formation and fluids leakage from the subglottic area) it should be also possible to reduce the incidence of late-onset VAP. ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Mechanical Ventilation
• Pneumonia, Ventilator-Associated

• NCT number: NCT00475579
• Study type: Interventional
• Source: Hospital Universitario de Canarias
• Status: Completed
• Phase: Phase 4
• Start date: March 2006
• Completion date: October 2006