Early Waning of Maternal Measles and Meningitis C Antibodies

Measles Clinical Trial

— EWMM  

Official title:

Observation Study on Early Waning of Maternal Measles and Meningitis C Antibodies

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02219061
• Other study ID #: GZCDC001
• Status: Recruiting
• Phase: N/A
• First received: August 13, 2014
• Last updated: September 16, 2014
• Start date: May 2014
• Est. completion date: December 2014

Study information

• Verified date: August 2014
• Source: Guangzhou Center for Disease Control and Prevention
• Contact: Chuanxi Fu, PhD
• Phone: +86 20 36055887
• Email: fuchuanxi[@]gmail.com
• Is FDA regulated: No
• Health authority: China: Health and Family Planning Commission of Guangdong Province
• Study type: Observational

Clinical Trial Summary

Maternal antibodies (measles and meningitis C) may wane in the first six months after birth.

• Geometric mean titers(GMTs) of measles and meningitis C.

• Follow-up on 0 month, 3rd month,5th month and 7th month after birth.

Description:

Measles and meningitis C are hot topics in China in recent years. Although China had set the goal of measles elimination, many measles cases were found to be those aged < 8 months and meningitis C is becoming public health issue since meningitis group A has been controlled at a very low level and little is known on C group. So the investigators designed the observation study on the two antibodies.

Maternal antibodies are supposed to wane after birth. Serums of the placenta(0 month), children of 3 months, 5 months and 7 months old will be collected and the geometric mean titers (GMTs) of measles and meningitis C will be confirmed by using the ELISA test.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 2014
• Est. primary completion date: October 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A to 7 Months

Eligibility

Inclusion Criteria:

• Healthy infants.

Exclusion Criteria:

• Infants with poor score.

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Measles
• Meningitis

Locations

Country	Name	City	State
China	Guangzhou Center for Disease Control and Prevention	Guangzhou	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Guangzhou Center for Disease Control and Prevention

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Geometric Mean Titer		Up to six months	No