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Measles Infection clinical trials

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NCT ID: NCT06153979 Recruiting - Measles Infection Clinical Trials

Investigation of Immune Amnesia Following Measles Infection in Select African Regions

Start date: January 16, 2024
Phase:
Study type: Observational

The goal of this observational study is to investigate the effects of measles virus (MeV) infection on pre-existing immunity, vaccine response, and susceptibility to subsequent illness in children aged 1-15 either with or without acute MeV infection.

NCT ID: NCT01486355 Recruiting - Measles Infection Clinical Trials

Additional Measles Vaccine at 4 Months of Age

Start date: August 2011
Phase: Phase 4
Study type: Interventional

Overall objective: To conduct a randomised controlled trial (RCT) to examine whether an early two-dose measles vaccination (MV) strategy at 4 and 9 months will reduce child mortality compared with the WHO strategy of one dose of MV at 9 months. Specific hypotheses Hypothesis I) Two doses of MV at 4 and 9 months compared with the standard dose of MV at 9 months will reduce mortality by 30% between 4 months and 5 years of age1. As in a previous trial it is expected that the beneficial effect is strongest for girls. Hypothesis II) Children receiving MV at 4 months in the presence of maternal measles antibodies (MatAb) will have 35% lower mortality between 4 months and 5 years of age than children receiving MV at 4 months with no detectable MatAb. Implications: These hypotheses are based on a previous RCT showing strong beneficial effects of providing an early measles vaccine, in particular among children with MatAb.