Malocclusion, Angle Class III Clinical Trial
Official title:
Clinical/Numerical Study of the Effects of Periodontal Ligament Stress Level on the Rate Bodily Tooth Movement
Verified date | June 2010 |
Source | University of Alberta, Graduate Orthodontic Program |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Health Canada |
Study type | Interventional |
Orthodontic treatment requires application of force systems to individual teeth or groups of
teeth, which results in a cellular response with periodontal ligament (PDL) and alveolar
bone remodeling. The forces applied must be of sufficient magnitude and duration to exceed
the normal physiologic threshold associated with daily oral function. Excessive force levels
will result in areas of tissue necrosis with delayed tooth movement and increased risk of
root resorption. Although orthodontic tooth movement is achieved in a large segment of the
population, the optimum force level has not been defined. The optimum force for tooth
movement depends on individual root geometry as well as biologic characteristics of
surrounding tissue including bone density, periodontal thickness, and fluid dynamics.
Because experimental and clinical techniques are generally limited to known complex force
systems, biomechanical modeling has become a necessity. Such models must be validated with
well-controlled clinical studies that evaluate orthodontic tooth movement over an extended
distance. The ultimate goal would be development of a computer simulation model to predict
tooth movement in the clinical setting.
The primary objective of this study is to test controlled clinical data with a biomechanical
model of the tooth and supporting tissues for distal movement of the human maxillary canine
tooth (of known root geometry) in response to various 3D force systems that produce
different levels of stress in the supporting tissues. Secondary objectives include
evaluation of rate of bodily tooth canine movement with two known compressive stress levels
(13 and 22 kPa), evaluation of three different reference systems to measure rate of tooth
movement, and evaluation of an implant placed in the roof of the mouth (palatal implant) for
orthodontic anchorage in adolescent patients.
The rate of translation (bodily) tooth movement of the maxillary canine tooth will be
significantly greater with 22kPa compared to 13kPa compressive stress applied to the
periodontal ligament, and this difference can be predicted by appropriate
mathematical/numerical models of the tooth and supporting tissues.
Status | Completed |
Enrollment | 20 |
Est. completion date | November 2005 |
Est. primary completion date | November 2005 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 12 Years to 16 Years |
Eligibility |
Inclusion Criteria: - Female adolescent (12-16 years old) orthodontic patients requiring upper first premolars extractions for overjet reduction. - Participants will be healthy and not taking any medications. - All participants will have healthy periodontal tissues and good oral hygiene. Exclusion Criteria: - Patients with medical contraindication for placement of a palatal implant. - All candidates who admit to tobacco utilization will be excluded. - Patients requiring lower dental extractions will also be excluded. - Pregnant patients or patients planning pregnancy will be excluded. |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Canada | Orthodontic Clinic - Department of Dentistry - University of Alberta | Edmonton | Alberta |
Lead Sponsor | Collaborator |
---|---|
University of Alberta, Graduate Orthodontic Program |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rate of space closure |
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