Clinical Trial Details
— Status: Active, not recruiting
Administrative data
| NCT number |
NCT05513651 |
| Other study ID # |
XJTU1AF-CRF-2020-023 |
| Secondary ID |
|
| Status |
Active, not recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
July 1, 2016 |
| Est. completion date |
December 30, 2030 |
Study information
| Verified date |
December 2023 |
| Source |
First Affiliated Hospital Xi'an Jiaotong University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
For all countries, chronic liver disease and liver cirrhosis is one of the important disease
burdens. Malnutrition is an important complication of liver cirrhosis, which always runs
through the course of liver cirrhosis. According to a lot of scientific research evidence, as
the consensus of experts all over the world, malnutrition in patients with liver cirrhosis is
closely related to poor outcome. Therefore, early and accurate identification of the risk of
malnutrition is very important to improve the prognosis of patients with liver cirrhosis.
The purpose of this study was to study the relationship between malnutrition-related indexes
and prognosis in patients with liver cirrhosis. 2000 patients with liver cirrhosis were
prospectively included, laboratory indexes related to malnutrition and other evaluation
indexes were recorded, and long-term follow-up was made to observe the short-term and
long-term prognosis of patients with liver cirrhosis. At the same time, a prognostic
prediction model was established based on multivariate Cox regression, and a series of
in-depth studies and verification were carried out on this basis.
Description:
Malnutrition is one of the most common complications associated with liver cirrhosis, which
is more likely to occur in patients with decompensated liver cirrhosis. Malnutrition will
further lead to muscle loss, that is, the occurrence of myomyositis, which is an important
cause of adverse outcome in patients with liver cirrhosis. it is associated with increased
risk of death, portal hypertension-related complications, increased infection rates and
longer hospital stays. At the same time, liver cirrhosis with portal hypertension leads to
esophageal and gastric varices and intestinal mucosal edema, which affects the function of
the digestive system and poses a greater challenge to the nutritional maintenance of patients
with liver cirrhosis. Therefore, timely nutritional assessment and early intervention
decision-making on admission is an important aspect of clinical management of patients with
liver cirrhosis.
For the screening of malnutrition in patients with liver cirrhosis, the commonly used
screening tools are MST, MUST, NRS-2002, RFH-NPT and so on. For the screened high-risk
population, further specific nutritional assessment is needed, there are four main types. The
first is a diet-related assessment conducted by a professional dietitian. The second is the
body composition analysis represented by muscle mass, such as bioelectrical impedance
analysis (BIA), CT, ultrasound and so on. The third is the functional evaluation, of which
the more common are five-meter walking speed and grip strength test. The fourth is part of
the comprehensive evaluation tools, represented by SGA and RFH-SGA.
