Malnutrition Clinical Trial
Official title:
Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development
Malnutrition is considered one of the most prevalent risk factors for morbidity and
mortality in children under five. An estimated 20% of children in the developing world are
malnourished [1] and poor nutrition is linked to more than half of all child deaths
worldwide [2]. Malnutrition in early childhood may lead to cognitive and physical deficits
and may cause similar deficits in future generations as malnourished mothers give birth to
low birth weight children [3]. In addition, malnutrition increases susceptibility and
incidence of infections and is associated with diminished response to vaccines.
The MAL-ED Project is designed to determine the impact of enteric infections/diarrhea that
alter gut function and impair children's nutrition, growth and development to help develop
new intervention strategies that can break the vicious enteric infection-malnutrition cycle
and reduce its global burden.
The overall objective of the MAL-ED Project is to quantify the associations of specific
enteric pathogens, measures of physical and mental development, micronutrient malnutrition,
gut function biomarkers, the gut microbiome, and immune responses in very young children in
resource-limited settings across eight sites that vary by culture, economics, geography, and
climate.
The central hypothesis of the MAL-ED Project is that infection (and co-infection) with
specific enteropathogens leads to impaired growth and development and to diminished immune
response to orally administered vaccines by causing intestinal inflammation and/or by
altering intestinal barrier and absorptive function. Data analyses will test for
associations between enteropathogen infections and growth/development to help illuminate:
- which micro-organisms or mixed infections are most frequently associated with growth
faltering and poor development; and
- at what age specific infections cause the most disruption to growth and development and
impair immune response.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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