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Study of Gene Expression Profiling and Immunological Mechanism Affects the Response of Immunotherapy

Malignant Tumor Clinical Trial

Official title:
Gene Expression Profiling and Immunological Mechanism Affects the Response of Malignant Cavity Effusion Towards DC-CIK Immunotherapy

Clinical Trial Summary

To investigate gene expression profile and immunological associated analysis relating to immunotherapy response of patients with malignant tumor presenting malignant cavity effusion after DC-CIK immunotherapy.

Clinical Trial Description

1. The patients with malignant cavity effusion are treated with dendritic cells (DC) plus cytokine induced killer cells (CIK) locally. 2. Malignant cavity effusion from cancer patients is obtained through puncture and is centrifugalized to get supernatant fluid and enrich cancer cells before and after the therapy. 3. The enriched cancer cells which are flash frozen, as well as the supernatant, are stored at -80°C until processing. 4. The T-Cell Receptor/B-Cell Receptor gene expression in cavity effusion is detected by micro-array to explore the mechanism that DC-CIK immunotherapy controls the malignant cavity effusion. 5. Statistical analysis is performed using unsupervised hierarchical cluster. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01884168
Study type Observational
Source Capital Medical University
Contact
Status Completed
Phase
Start date March 2013
Completion date May 2023
View Details
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