Malignant Solid Tumor Clinical Trial
Official title:
Open-label, Single Arm, Tumor Imaging and Dosimetry Study of I-124 PGN650 in Advanced Solid Tumors
Tumor Imaging of I-124 PGN65 in Solid Tumors
Up to 12 patients (6 men and 6 women) will be enrolled in this open-label, single-arm, tumor imaging and dosimetry study of I-124 PGN650 in solid tumors. All eligible patients who give written, informed consent and meet all inclusion criteria and no exclusion criteria, and whose laboratory results are within specified limits at the screening visit, will be enrolled. All study subjects will receive a single intravenous (IV) dose of I-124 PGN650. Study subjects will have whole body PET/CT imaging at three different timepoints with all patients having PET/CT at 0 to 60 minutes after injection of I-124 PGN650. Study subjects will then be assigned to either a 3 to 5-hour or 6 to 8-hour timepoint and either an 18 to 26 hour or 42 to 52 hour post-injection timepoint. Tumor and whole body radioactivity distribution will be measured. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT01846429 -
Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain
|
Phase 1 | |
| Completed |
NCT01359982 -
Safety and Pharmacokinetic Study of RRx-001 in Cancer Subjects
|
Phase 1 | |
| Completed |
NCT01648764 -
A Study of LY2334737 in Participants With Cancer That is Advanced and/or Has Spread
|
Phase 1 | |
| Completed |
NCT00725634 -
A Phase 1 Dose-Escalation Study in Advanced Solid Tumors, Lymphomas or Multiple Myeloma
|
Phase 1 | |
| Recruiting |
NCT04083599 -
GEN1042 Safety Trial and Anti-tumor Activity in Subjects With Malignant Solid Tumors
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05141474 -
Assessment of the Safety and Tolerability of ex Vivo Next-generation Neoantigen-selected Tumor-infiltrating Lymphocyte (TIL) Therapy in Advanced Epithelial Tumors and Immune Checkpoint Blockade (ICB) Resistant Solid Tumors
|
Early Phase 1 | |
| Active, not recruiting |
NCT02999750 -
EXtendedAnalysis for Cancer Treatment
|
N/A | |
| Completed |
NCT01457118 -
An Extension Study of NKTR-102 in Cancer Patients Previously Enrolled in NKTR-102 Studies
|
Phase 2 | |
| Active, not recruiting |
NCT05539157 -
Study to Evaluate JCXH-211 as Monotherapy in Patients With Malignant Solid Tumors
|
Phase 1 | |
| Recruiting |
NCT04571892 -
A Clinical Study to Observe the Safety and Efficacy of ScTIL210 in the Treatment of Malignant Solid Tumors
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05468359 -
Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04168528 -
Phase I/IIa Study of 68GaNOTA-Anti-MMR-VHH2 for PET/CT
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04145622 -
Study of Ifinatamab Deruxtecan (DS-7300a, I-DXd) in Participants With Advanced Solid Malignant Tumors
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06057038 -
A Safety Trial of GEN1042 in Japanese Subjects With Malignant Solid Tumors
|
Phase 1 | |
| Completed |
NCT02844400 -
Cancer Patients' Performance Status Assessed Using Cardiopulmonary Exercise Testing and Wearable Data Generation
|
||
| Completed |
NCT00452413 -
A Study of Enzastaurin and Erlotinib in Participants With Solid Tumors and Lung Cancer
|
Phase 1/Phase 2 | |
| Completed |
NCT03553108 -
A Study Using Olaparib Tablets for Subjects With Advanced Solid Tumours.
|
Phase 1 | |
| Recruiting |
NCT06391775 -
Trial to Assess the Safety and Preliminary Efficacy of GEN1055 on Malignant Solid Tumors as Monotherapy and as Combination Therapy
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04076137 -
Targeted T-cell Therapy in Solid Tumors
|
Early Phase 1 | |
| Terminated |
NCT03192345 -
A First-in-human Study of the Safety, Pharmacokinetics, Pharmacodynamics and Anti-tumor Activity of SAR439459 Monotherapy and Combination of SAR439459 and Cemiplimab in Patients With Advanced Solid Tumors
|
Phase 1 |