| Eligibility |
Inclusion Criteria:
1. Histologically or cytologically confirmed cancer of any primary tumor type.
2. Malignant pleural effusion requiring drainage that is histologically or cytologically
confirmed;
3. Eastern Cooperative Oncology Group (ECOG) performance status: 0 to 2. Patients with an
ECOG performance status of 3 may be included if the Investigator determines that
removal of pleural fluid would improve their performance status to 2 or better.
4. Life expectancy of at least 8 weeks.
5. Age =18 years and = 75 years;.
6. Body weight =45 kg and body mass index =17 kg/m2.
7. Adequate hematologic function, defined as:
1. Platelet count =80,000/µL;
2. Prothrombin time and activated partial thromboplastin time =1.5 times the upper
limit of normal (ULN);
3. Absolute neutrophil count =1,500 µL;
4. Hemoglobin =8 g/dL (transfusion and erythropoietic agents are allowed). In case
there is existence of active bleeding or other persistent condition of either
increased destruction or impaired production of erythrocytes, which may require
repeated transfusion or erythropoietic treatment, the eligibility must be
discussed with the Sponsor on a case by-case basis prior to randomization.
5. Ablumin=35g/L
8. Adequate renal function, defined as serum creatinine =2.0 times ULN and creatinine
clearance >50 mL/minute.
9. Adequate liver function, defined as:
1. Aspartate aminotransferase and alanine aminotransferase =2.0 times ULN for
patients without liver metastases, or =5 times ULN in the presence of liver
metastases;
2. Bilirubin =2.0 times ULN, unless patient has known Gilberts syndrome.
10. Female patients of childbearing potential (excluding women who have undergone surgical
sterilization or are menopausal, defined as no menstrual periods for 1 year or more
without any other medical reasons) are eligible if they have negative serum pregnancy
test result 7 days before the first dose of SCB-313 and are willing to use an
effective method of birth control/contraception to prevent pregnancy until 6 months
after discontinuation of SCB-313.
11. Both men and women of reproductive potential must agree to use effective contraception
during the study and for 6 months after discontinuation of SCB 313.
12. Note: Contraceptive methods that are considered highly effective areas follows: total
abstinence, intrauterine device, double barrier method (such as condom plus diaphragm
with spermicide), contraceptive implant, hormonal contraceptives (contraceptive pills,
implants, transdermal patches, hormonal vaginal devices, or injections with prolonged
release), or vasectomized partner with confirmed azoospermia.
13. Willing to attend follow-up visits according to study protocol.
Exclusion Criteria:
1. Significantly loculated pleural effusions not amenable to drainage or patient is
unlikely to benefit from intrapleural therapy.
2. Any anti-tumor drug other than the systemic anti-tumor therapy that the subject has
stably used and any treatment that may have an effect on the control of pleural
effusions. Prior therapy with monoclonal antibody should be stopped per Investigators
judgement making sure delayed side effects will not interfere with the DLT evaluation
period after SCB-313 therapy.
3. Acute or chronic infection (such as tuberculosis) requiring antiviral or intravenous
antibiotics within 2 weeks prior to enrollment.
4. Clinical unstable or uncontrolled concomitant hematologic, cardiovascular, pulmonary,
hepatic, renal, pancreatic, or endocrine diseases.
5. History of gross hemoptysis (>2.5 mL) within 3 months prior to enrollment.
6. Residual adverse events (AEs) > Grade 2 from previous treatment.
7. Evidence or suspicion of relevant psychiatric impairment, including alcohol or
recreational drug abuse.
8. Myocardial infarction within 6 months prior to treatment and/or prior diagnoses of
congestive heart failure (New York Heart Association Class III or IV), unstable
angina, unstable cardiac arrhythmia requiring medication, and/or long QT syndrome or
QT/QTc interval >450 msec at Baseline.
9. Uncontrolled hypertension defined as systolic blood pressure =160 mmHg and/or
diastolic blood pressure =100 mmHg confirmed upon repeated measures (note: no more
than 3 repeated measures allowed).
10. Major surgery (open procedures) within 4 weeks prior to enrollment.
11. Patient with ileus within 30 days prior to Screening.
12. Positive serology test for human immunodeficiency virus,Syphilis, Hepatitis B
virus(HBV) and/or Hepatitis C virus(HCV).
13. Live vaccine within 2 weeks prior to enrollment.
14. Scheduled participation in another clinical study involving an investigational product
or device during the DLT observation period of this study.
15. Previous treatment with a TRAIL-based therapy or death receptor 4/5 agonist therapy.
16. Known or suspected hypersensitivity to any component of SCB-313.
17. Any further condition which, in the opinion of the Investigator, may result in undue
risk of the patient by participating in the present study.
18. Untreated or uncontrolled central nervous system metastatic disease, leptomeningeal
disease, or cord compression.
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