Bortezomib and Cisplatin as First-Line Therapy in Treating Patients With Malignant Mesothelioma

Malignant Mesothelioma Clinical Trial

Official title:

Phase II Study of Bortezomib (VELCADE) With Cisplatin as First Line Treatment of Malignant Mesothelioma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00458913
• Other study ID #: EORTC-08052
• Secondary ID: JJPRD-26866138CA
• Status: Completed
• Phase: Phase 2
• Start date: February 2007
• Est. completion date: March 2012

Study information

• Verified date: July 2018
• Source: European Organisation for Research and Treatment of Cancer - EORTC
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving bortezomib together with cisplatin may kill more tumor cells.

PURPOSE: This phase II trial is studying the side effects and how well giving bortezomib together with cisplatin works as first-line therapy in treating patients with malignant mesothelioma.

Description:

OBJECTIVES:

• Determine the activity and safety of bortezomib and cisplatin as first-line treatment in patients with malignant mesothelioma.

• Validate the use of progression-free survival rate as a primary endpoint for the design of phase II mesothelioma trials.

OUTLINE: This is a nonrandomized, open-label, multicenter study.

Patients receive cisplatin IV over 1 hour on day 1 and bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11. Treatment repeats every 3 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed periodically.

PROJECTED ACCRUAL: A total of 76 patients will be accrued for this study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 82
• Est. completion date: March 2012
• Est. primary completion date: April 2010
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 120 Years

Eligibility

DISEASE CHARACTERISTICS:

• Histologically confirmed pleural malignant mesothelioma, meeting 1 of the following criteria:

• Recurrent disease after radical surgery

• Disease not considered suitable for radical treatment

• Measurable or evaluable disease

• No clinical evidence of brain or leptomeningeal metastases

PATIENT CHARACTERISTICS:

• WHO performance status 0-1

• Life expectancy > 12 weeks

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• Absolute neutrophil count > 1,500/mm³

• Platelet count > 100,000/mm³

• Creatinine clearance > 60 mL/min OR > 50 mL/min

• ALT and AST < 2.5 times upper limit of normal (ULN) (< 5 times ULN if liver metastases present)

• Bilirubin < 1.5 times ULN

• No concurrent secondary malignancy except carcinoma in situ of the cervix or adequately treated basal cell skin cancer

• No other malignancy treated within the past 5 years

• Melanoma, breast cancer, or hypernephroma treated within the past 5 years and without recurrence are allowed

• No uncontrolled or severe cardiovascular disease, including any of the following:

• Myocardial infarction within the past 6 months

• New York Heart Association class III-IV heart failure

• Uncontrolled angina

• Clinically significant pericardial disease or cardiac amyloidosis

• No infiltrative pulmonary or pericardial disease

• No preexisting peripheral neuropathy

• No known or suspected allergy or intolerance to boron, mannitol, or heparin, if an indwelling catheter is used

• No psychological, familial, sociological, or geographical condition that would preclude protocol compliance

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• No prior systemic chemotherapy for mesothelioma

• No other concurrent antineoplastic agents except medications that may have antineoplastic activity but are taken for other reasons (e.g., megestrol acetate, cyclooxygenase-2 inhibitors, or bisphosphonates)

• No other concurrent experimental agents

Related Conditions & MeSH terms

• Lung Neoplasms
• Malignant Mesothelioma
• Mesothelioma

Intervention

Drug:
• bortezomib

• cisplatin

Locations

Country	Name	City	State
United Kingdom	Royal Marsden - Surrey	Sutton	England

Sponsors (1)

Lead Sponsor	Collaborator
European Organisation for Research and Treatment of Cancer - EORTC

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Progression-free survival (PFS) rate at 18 weeks
Secondary	Overall objective response rate
Secondary	Symptomatic response rate
Secondary	Safety as measured by NCI CTCAE v3.0 and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity questionnaire
Secondary	Duration of PFS
Secondary	Overall survival