Pemetrexed Disodium and Cisplatin Followed By Surgery and Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma

Malignant Mesothelioma Clinical Trial

Official title:

A Phase II Feasibility Trial of Induction Chemotherapy Followed by Extrapleural Pneumonectomy and Postoperative Radiotherapy in Patients With Malignant Pleural Mesothelioma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00227630
• Other study ID #: EORTC-08031
• Secondary ID: EORTC-080312004-
• Status: Completed
• Phase: Phase 2
• First received: September 26, 2005
• Last updated: July 17, 2012
• Start date: July 2005

Study information

• Verified date: July 2012
• Source: European Organisation for Research and Treatment of Cancer - EORTC
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Drugs used in chemotherapy, such as pemetrexed disodium and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Pemetrexed disodium may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy before surgery may shrink the tumor so that it can be removed. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.

PURPOSE: This phase II trial is studying how well giving pemetrexed disodium and cisplatin followed by surgery and radiation therapy works in treating patients with malignant pleural mesothelioma.

Description:

OBJECTIVES:

Primary

• Determine the feasibility of neoadjuvant chemotherapy comprising pemetrexed disodium and cisplatin followed by extrapleural pneumonectomy and high-dose postoperative 3D-conformal radiotherapy, in terms of 90-day progression-free survival, in patients with malignant pleural mesothelioma.

Secondary

• Determine the toxicity of this regimen in these patients.

• Determine progression-free survival and overall survival of patients treated with this regimen.

OUTLINE: This is a non-randomized, multicenter study.

• Neoadjuvant chemotherapy: Patients receive pemetrexed disodium IV over 10 minutes and cisplatin IV over 2 hours on day 1. Treatment repeats every 3 weeks for up to 3 courses in the absence of disease progression or unacceptable toxicity. Patients are evaluated 3 weeks after completion of neoadjuvant chemotherapy. Patients without disease progression proceed to surgery.

• Extrapleural pneumonectomy: Within 21-56 days after completion of neoadjuvant chemotherapy, patients undergo extrapleural pneumonectomy. Patients are evaluated 30 days after surgery. Patients without disease progression undergo high-dose 3D-conformal radiotherapy.

• High-dose 3D-conformal radiotherapy: Beginning 30-84 days after surgery, patients undergo high-dose 3D-conformal radiotherapy daily for 30 days.

After completion of study treatment, patients are followed on days 42 and 90, every 3 months for 1 year, and then every 6 months thereafter.

PROJECTED ACCRUAL: A total of 52 patients will be accrued for this study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 59
• Est. primary completion date: August 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A to 69 Years

Eligibility

DISEASE CHARACTERISTICS:

• Histologically confirmed malignant pleural mesothelioma

• All subtypes allowed

• T1-3, N0-1, M0 disease

• No N2 or N3 involvement confirmed by mediastinoscopy within 21 days before study entry

• No clinical invasion of mediastinal structures (e.g., heart, aorta, spine, esophagus)

• No wide-spread chest wall invasion except focal chest wall lesions

• No clinical or radiological evidence of shrinking hemithorax

• No clinically significant third-space fluid (e.g., pleural effusions or ascites) that cannot be managed with thoracentesis or pleurodesis

PATIENT CHARACTERISTICS:

Age

• Under 70

Performance status

• WHO 0-1

Life expectancy

• Not specified

Hematopoietic

• WBC > 3,500/mm^3

• Absolute neutrophil count > 1,500/mm^3

• Platelet count > 100,000/mm^3

• Hemoglobin = 11 g/dL

Hepatic

• AST and ALT < 1.5 times upper limit of normal (ULN)

• Bilirubin < 1.5 times ULN

• Alkaline phosphatase < 1.5 times ULN

Renal

• Creatinine clearance = 60 mL/min

• Acceptable (predicted) post-radiotherapy renal function by semiquantitative isotope renography, with a relative contribution of the contralateral kidney of = 40%

Pulmonary

• See Disease Characteristics

Other

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception during and for 3 months after completion of study treatment

• Deemed to be fit enough to undergo study treatment

• No preexisting sensory neurotoxicity > grade 1

• No uncontrolled infection

• No prior or concurrent melanoma, breast cancer, or hypernephroma

• No other malignancy within the past 5 years except carcinoma in situ of the cervix or adequately treated basal cell skin cancer

• No psychological, familial, sociological, or geographical condition that would preclude study compliance

PRIOR CONCURRENT THERAPY:

Biologic therapy

• No concurrent immunotherapy

• No concurrent routine use of colony-stimulating factors during neoadjuvant chemotherapy

• Concurrent secondary prophylactic use allowed during neoadjuvant chemotherapy

• No concurrent secondary prophylactic use of colony-stimulating factors during post-operative radiotherapy

Chemotherapy

• No prior chemotherapy for mesothelioma

Endocrine therapy

• No concurrent hormonal cancer therapy

Radiotherapy

• No prior radiotherapy to the lower neck, thorax, or upper abdomen

Surgery

• See Disease Characteristics

Other

• No other concurrent anticancer therapy

• No other concurrent experimental medications

• No nonsteroidal anti-inflammatory drugs or salicylates for 2 days before, during, and 2 days after administration of neoadjuvant chemotherapy (5 days before and 2 days after for drugs with a long half-life [e.g., naproxen, piroxicam, diflunisal, or nabumetone])

Study Design

Allocation: Non-Randomized, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Lung Neoplasms
• Malignant Mesothelioma
• Mesothelioma

Intervention

Drug:
• cisplatin

• pemetrexed disodium

Procedure:
• adjuvant therapy

• conventional surgery

• neoadjuvant therapy

Radiation:
• radiation therapy

Locations

Country	Name	City	State
Belgium	Universitair Ziekenhuis Antwerpen	Edegem
Italy	Istituto Nazionale per la Ricerca sul Cancro	Genoa
Italy	Azienda Ospedaliera Di Parma	Parma
Italy	Universita Degli Studi di Udine	Udine
Netherlands	Sint Antonius Ziekenhuis	Nieuwegein
Netherlands	Daniel Den Hoed Cancer Center at Erasmus Medical Center	Rotterdam
United Kingdom	Edinburgh Cancer Centre at Western General Hospital	Edinburgh	Scotland
United Kingdom	Princess Royal Hospital at Hull and East Yorkshire NHS Trust	Hull	England

Sponsors (1)

Lead Sponsor	Collaborator
European Organisation for Research and Treatment of Cancer - EORTC

Countries where clinical trial is conducted

Belgium,  Italy,  Netherlands,  United Kingdom, 

References & Publications (2)

O'Brien ME, Konopa K, Lorigan P, Bosquee L, Marshall E, Bustin F, Margerit S, Fink C, Stigt JA, Dingemans AM, Hasan B, Van Meerbeeck J, Baas P. Randomised phase II study of amrubicin as single agent or in combination with cisplatin versus cisplatin etopos — View Citation

Van Schil PE, Baas P, Gaafar R, Maat AP, Van de Pol M, Hasan B, Klomp HM, Abdelrahman AM, Welch J, van Meerbeeck JP; European Organisation for Research and Treatment of Cancer (EORTC) Lung Cancer Group. Trimodality therapy for malignant pleural mesothelio — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Feasibility in terms of 90-day progression-free survival			No
Secondary	Toxicity			Yes
Secondary	Progression-free survival			No
Secondary	Overall survival			No