Malignant Mesothelioma Clinical Trial
Official title:
Phase II Study on Tomusex in Malignant Mesothelioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of raltitrexed in treating patients who
have malignant mesothelioma that cannot be surgically removed.
OBJECTIVES: I. Determine the therapeutic activity and toxicities of raltitrexed in patients
with inoperable malignant mesothelioma. II. Determine the objective response rate and
duration of response in patients treated with this regimen.
OUTLINE: This is a multicenter study. Within 2 weeks of staging procedures, patients receive
raltitrexed IV over 15 minutes on day 1. Treatment repeats every 3 weeks for a maximum of 8
courses in the absence of disease progression or unacceptable toxicity. Patients are
followed every 6 weeks until disease progression and then every 8 weeks thereafter for
survival.
PROJECTED ACCRUAL: A total of 24 patients will be accrued for this study.
;
Primary Purpose: Treatment
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