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NCT05486247 Clinical Trial

Molecular Characterization of Gliomas Using a Broad Next Generation Sequencing (NGS)Panel

Malignant Glioma Clinical Trial

Official title:
Molecular Characterization of Gliomas Using a Broad NGS Panel

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05486247
Other study ID # NGSGLIOMA
Secondary ID
Status Completed
Phase
First received
Last updated
Start date February 4, 2015
Est. completion date May 1, 2022

Study information
Verified date August 2022
Source Hellenic Cooperative Oncology Group
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Gliomas are the most common malignant primary brain tumors with poor prognosis. The genotyping of tumors using NGS platforms enables the identification of genetic alterations that constitute diagnostic, prognostic and predictive biomarkers.Here in, we investigated the molecular profile of 32 tumor samples from 32 patients with high grade gliomas by implementing a broad 80-gene targeted NGS panel while reporting their clinicopathological characteristics and outcomes.

Recruitment information / eligibility
Status Completed
Enrollment 32
Est. completion date May 1, 2022
Est. primary completion date December 1, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: Diagnosis of high grade glioma based on tissue biopsy Exclusion Criteria:

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Hellenic Cooperative Oncology Group

Outcome
Type Measure Description Time frame Safety issue
Primary The prevalence of genetic alterations in patients with high grade glioma using a 80 gene NGS panel The prevalence of genetic alterations in patients with high grade glioma using a 80 gene NGS panel April 2019 - December 2021
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