Malignant Glioma Clinical Trial
Official title:
Rotating Frame Relaxation and Diffusion Weighted Imaging of Human Gliomas
Grading of gliomas is of significant clinical importance since the prognosis as well as the
treatment of choice are distinct in low-grade and high-grade gliomas. With standard MRI
modalities, however, a reliable distinction is often impossible. Moreover, the gold standard
for glioma grading by histopathology may also have limitations due to unrepresentative tumor
samples. Therefore, more advanced MRI techniques are urgently needed that would have higher
sensitivity and specificity in the definition of tumor type, grade and extent.
Assessment of radiologic response for high-grade gliomas utilizes the updated RANO criteria
12 weeks after completion of chemoradiotherapy. However, there is an urgent need to identify
nonresponding patients earlier, preferentially midtreatment in order to consider alternative
treatment strategies. Imaging biomarkers, such as diffusion weighted MR imaging (DWI), have
provided promising results in assessing early treatment response. Furthermore, a serum
biomarker with diagnostic value could improve tumor follow-up and clinical management of
gliomas.
The aim of our study is to develop novel imaging protocols suitable for the magnetic
resonance imaging (MRI) of glioma using advanced MRI techniques such as rotating frame
imaging, novel DWI acquisition and post-processing methods We also study the correlation
between advanced MRI parameters and histopathology of the tumor specimen. In addition, early
treatment response is assessed with advanced MRI parameters at 3 week and 10 week after
initiation of radiotherapy. Finally, our objective is to study the association between serum
biomarkers and corresponding MRI with potential tumor progression.
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