Malignant Glioma Clinical Trial
Official title:
A Phase I/II Clinical Trial Evaluating DC Activated Cytokine-induced Killer Cell(DCIK) Combined With DC Treatment for Glioma
Malignant gliomas are very aggressive and among the most common of brain tumors. A diagnosis
carries with it a median survival of approximately 12 months, with 90 - 95% of patients
surviving less than 2 years. The current standard treatment of surgical resection followed
by radiation therapy and chemotherapy has not substantially prolonged survival.
Dendritic cells (DCs) are immune cells that form part of the mammalian immune system. Their
main function is to process antigen material and present it on the surface to other cells of
the immune system, thus functioning as antigen-presenting cells.In the present study, DCs
were used for antigen presentation of glioma antigens to directly induce a cytotoxic T-cell
response. Cytokine-induced killer (CIK)cells are shown to be a heterogeneous population, and
the major population expresses both the T cell marker CD3 and the NK cell marker CD56, and
is termed NKT cells, which has shown significant anti-tumor activity in both clinical trials
and animal studies.
Furthermore, CIK cells are able to expand significantly when they are cultured with DCs, and
the CIK cells activated by DCs stimulation (DCIKs)have a characteristic which cytotoxic
activity enhanced and show increased anti-tumor activity.
This study aimed to evaluate the clinical efficacy of DCIK cells treatment combined with DCs
following tumor resection and radiotherapy in patients with malignant glioma.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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