Rifaximin for Preventing Acute Graft Versus Host Disease (AGVHD)

Status Completed

Clinical Trial Summary

Acute graft versus host disease is a frequent and often life threatening complication of allogeneic blood and marrow transplantation. The bacteria that normally reside in the intestine play a critical role in its development. Injury to the lining of the bowel that results from the high dose chemotherapy or radiation that transplant patients receive during the week preceding the transplant allows the bacteria to invade the intestines and spread to nearby lymph nodes. This, in turn, causes inflammation which has been shown to promote GVHD. Both pre-clinical and clinical research has demonstrated that oral antibiotics can prevent graft versus host disease by inhibiting these gut bacteria. Rifaximin has several features that suggest it could be effective in preventing GVHD. Rifaximin prophylaxis might also provide an added benefit by protecting highly immunocompromised transplant patients from severe bacterial infections. This pilot trial will allow the investigators to determine the feasibility of using Rifaximin for prevention of GVHD and infection in patients undergoing allogeneic blood and marrow transplantation. The preliminary results will be used to plan a more definitive trial.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00967096
Study type	Interventional
Source	Emory University
Contact
Status	Completed
Phase	Phase 1
Start date	April 2007
Completion date	April 2009

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05640115` - Obstruction of Malignancy: Percutaneous Renal vs Endoscopic Stent	Early Phase 1
Recruiting	`NCT02891642` - Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid
Completed	`NCT02282449` - Power Injectable Versus a Non-Power Injectable, Upper Arm, TIVAD for Chemotherapy	N/A
Completed	`NCT01212731` - Skull Base and Low Grade Glioma Neurocognitive Magnetic Resonance Imaging (MRI) Study
Completed	`NCT01199822` - Study of the Safety and Pharmacokinetics of IMC-3G3 in Japanese Patients With Solid Tumors	Phase 1
Recruiting	`NCT04122469` - The Role of Stereo-tActic BoDy RadIotherApy iN Oligo-Progressive MalignanT Disease	N/A
Recruiting	`NCT03561727` - Risk Factors for Development of Incisional Hernia in Transverse Incisions	N/A
Terminated	`NCT03251924` - A Dose Escalation and Combination Immunotherapy Study to Evaluate BMS-986226 Alone or in Combination With Nivolumab or Ipilimumab in Patients With Advanced Solid Tumors	Phase 1/Phase 2
Active, not recruiting	`NCT03997968` - A Phase 1/2 Study of CYT-0851 in B-Cell Malignancies and Advanced Solid Tumors	Phase 1/Phase 2
Active, not recruiting	`NCT00092222` - Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity	Phase 2
Recruiting	`NCT05770102` - DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition	Phase 2/Phase 3
Recruiting	`NCT05886764` - Novel Outreach Methods to Increase Enrollment to Early Phase Clinical Trials	N/A
Not yet recruiting	`NCT05992363` - Tandem Polyurethane Stents Compared to Single Silicone Stent for Malignant Ureteral Obstruction	Phase 3
Recruiting	`NCT05761366` - Application of 18F-PSMA PET / CT Imaging in Prostate Specific Membrane Antigen Positive Tumor	Phase 2
Recruiting	`NCT04887545` - Immune- and Microenvironment- Proteogenomics Profiling for Classifying Lung Cancer Patients
Completed	`NCT03061955` - Safety and Efficacy of Concurrent Administration of Influenza Vaccine in Patients Undergoing Anti-PD-1 Immunotherapy (Nivolumab, Pembrolizumab)
Completed	`NCT03909464` - Non-Invasive Neurosensory Testing For Chemotherapy-Induced Peripheral Neuropathy
Active, not recruiting	`NCT02649491` - Using an Electronic Nose to Predict Gastrointestinal Consequences of Pelvic Radiotherapy	N/A
Recruiting	`NCT02776995` - Tumor Monitoring Using Thermography During Radiation Therapy	N/A
Active, not recruiting	`NCT01242072` - Intravenous Palifosfamide-tris in Combination With Etoposide and Carboplatin in Patients With Malignancies	Phase 1