Malignancies Clinical Trial
Official title:
A Phase 1, Open-Label, Dose-Escalation and Cohort Expansion First-in-Human Study of the Safety, Tolerability, Activity and Pharmacokinetics of REGN3767 (Anti-LAG-3 mAb) Administered Alone or in Combination With REGN2810 (Anti-PD-1 mAb) in Patients With Advanced Malignancies
The primary objectives in the dose escalation phase are to evaluate safety and pharmacokinetics (PK) in order to determine the selected dose level(s) for expansion of REGN3767 as monotherapy and in combination with cemiplimab in patients with advanced malignancies, including lymphoma. The primary objectives in the dose expansion phase are to assess preliminary anti-tumor activity of REGN3767 alone and in combination with cemiplimab (separately by cohort) as measured by objective response rate (ORR).
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03384511 -
The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies.
|
Phase 4 | |
Completed |
NCT03236857 -
A Study of the Safety and Pharmacokinetics of Venetoclax in Pediatric and Young Adult Patients With Relapsed or Refractory Malignancies
|
Phase 1 | |
Not yet recruiting |
NCT05602103 -
Cancer Therapy-related Cardiac Dysfunction Occuring in Children Treated by Anticancer Drugs for Malignancies
|
||
Terminated |
NCT00329329 -
Study of Satraplatin With Capecitabine to Treat Advanced Solid Malignancies
|
Phase 1 | |
Completed |
NCT00316511 -
Study of L-NDDP (Aroplatin) in Patients With Advanced Solid Malignancies or B-Cell Lymphoma
|
Phase 1 | |
Withdrawn |
NCT05253105 -
A Clinical Study of TAB006 in Patients With Previously Treated, Advanced Malignancies
|
Phase 1 | |
Completed |
NCT02521389 -
Assessment of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Various Formulations and Doses of PWT-143
|
Phase 1 | |
Completed |
NCT01407380 -
Study of PWT33597 Mesylate in Subjects With Advanced Malignancies
|
Phase 1 | |
Completed |
NCT01404728 -
Longitudinal Evaluation Study of Vaginal Stenosis With and Without Pelvic Radiation Therapy
|
N/A | |
Active, not recruiting |
NCT03678883 -
9-ING-41 in Patients With Advanced Cancers
|
Phase 2 | |
Not yet recruiting |
NCT05929495 -
Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma
|
Phase 2 | |
Completed |
NCT02257476 -
Extended Infusion Carfilzomib on a Weekly Schedule in Patients With Advanced Solid Tumors
|
Phase 1 | |
Completed |
NCT00320827 -
Study of CS-1008 in Patients With Advanced Solid Malignancies and Lymphomas (Without Leukemic Component)
|
Phase 1 |