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A Study of the Plasmodium Falciparum Malaria Vaccine Candidate Pfs48/45 in Matrix-M Adjuvant in the UK

Malaria Clinical Trial

Official title:
A Phase Ia Study to Assess Safety and Immunogenicity of the Plasmodium Falciparum Malaria Vaccine Candidate Pfs48/45 in Matrix-M Adjuvant in Healthy Adults Living in the UK

Clinical Trial Summary

This is an open label, single-site, first-in-human, dose-escalation Phase Ia study to assess safety and immunogenicity of the Plasmodium falciparum malaria vaccine candidate Pfs48/45 in Matrix-M adjuvant in healthy adults living in the UK

Clinical Trial Description

Volunteers will be recruited into one of three groups (n=8-10 per group) at the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), Oxford over approximately 12 months. All volunteers will receive three dose of Pfs48/45 in 50 µg Matrix-M, administered intramuscularly and given four weeks apart. Enrolment will be staggered with clinical and safety reviews, follow-up visits and monitoring via a diary card. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05400746
Study type Interventional
Source University of Oxford
Contact Volunteer Recruitment Co-ordinator Volunteer Recruitment Co-ordi
Phone 01865 611424
Email vaccinetrials@ndm.ox.ac.uk
Status Recruiting
Phase Early Phase 1
Start date November 2, 2022
Completion date May 30, 2023
View Details
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