Malaria, Falciparum Clinical Trial
Official title:
Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma.
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
Status | Completed |
Enrollment | 43 |
Est. completion date | September 2013 |
Est. primary completion date | September 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 12 Years to 16 Years |
Eligibility |
Inclusion Criteria: - Children aged 12 to 16 years - Body weight > 30 kg - no chronic medical illnesses - no intake of vitamin/mineral supplements 2 weeks before the study and until the last blood drawing - For each of the 4 arms the respective disease needs to be present (symptomatic malaria, asymptomatic malaria, hookworm infection, S. haematobium infection) without any other concurrent infection Exclusion Criteria: |
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
Côte D'Ivoire | Taabo Cité Hospital | Taabo |
Lead Sponsor | Collaborator |
---|---|
Swiss Federal Institute of Technology |
Côte D'Ivoire,
Kastenmayer P, Davidsson L, Galan P, Cherouvrier F, Hercberg S, Hurrell RF. A double stable isotope technique for measuring iron absorption in infants. Br J Nutr. 1994 Mar;71(3):411-24. — View Citation
Rohner F, Zimmermann MB, Amon RJ, Vounatsou P, Tschannen AB, N'goran EK, Nindjin C, Cacou MC, Té-Bonlé MD, Aka H, Sess DE, Utzinger J, Hurrell RF. In a randomized controlled trial of iron fortification, anthelmintic treatment, and intermittent preventive treatment of malaria for anemia control in Ivorian children, only anthelmintic treatment shows modest benefit. J Nutr. 2010 Mar;140(3):635-41. doi: 10.3945/jn.109.114256. Epub 2010 Jan 27. — View Citation
Walczyk T, Davidsson L, Zavaleta N, Hurrell RF. Stable isotope labels as a tool to determine the iron absorption by Peruvian school children from a breakfast meal. Fresenius Journal of Analytical Chemistry 359: 445-449, 1997.
Wegmüller R, Camara F, Zimmermann MB, Adou P, Hurrell RF. Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire. J Nutr. 2006 Jul;136(7):1814-20. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Isotope absorption into blood stream | Day 15 | No | |
Primary | Isotope absorption into blood stream | Day 43 | No | |
Secondary | Isotope incorporation into erythrocytes | Day 15 | No | |
Secondary | Biochemical parameters of iron status and infection | Day 1 | No | |
Secondary | Biochemical parameters of iron status and infection | Day 15 | No | |
Secondary | Biochemical parameters of iron status and infection | Day 29 | No | |
Secondary | Biochemical parameters of iron status and infection | Day 43 | No | |
Secondary | Isotope incorporation into erythrocytes | Day 43 | No |
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