Malaria, Falciparum Clinical Trial
Official title:
The Efficacy of Re-treatment With Sulfadoxine-pyrimethamine in Children With Recrudescent Malaria in Guinea-Bissau
Children participating in a study evaluating the efficacy of chloroquine and amodiaquine for
the treatment of malaria will, if getting malaria during follow-up, be re-treated with
sulfadoxine-pyrimethamine (SP) in accordance with the recommendations of the National
Malaria Programme.
To compare the actual efficacy of SP with that in 1995 - 1996 we, the investigators of the
Bandim Health Project, will visit these children once a week for 5 weeks. A finger prick
blood sample will be collected for a malaria test.
Children with malaria during follow-up will be treated according to the guidelines of the
Bandim Health Centre.
Status | Completed |
Enrollment | 60 |
Est. completion date | March 2004 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A to 15 Years |
Eligibility |
Inclusion Criteria: - Malaria symptoms plus positive malaria film - > 20 parasites per 200 leukocytes - Treatment failure in a study comparing chloroquine and amodiaquine - Informed consent Exclusion Criteria: - Stated allergy to sulfadoxine and/or pyrimethamine |
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Guinea-Bissau | Bandim Health Project | Apartado 861 | Bissau |
Lead Sponsor | Collaborator |
---|---|
Bandim Health Project |
Guinea-Bissau,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Re-appearing parasitaemia |
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