Magnetic Resonance Imaging Clinical Trial
Official title:
Influence of Biological Sex and Age on Cerebral Blood Flow and Vessel Function During Exercise: a Pilot Study
Brain blood flow will be measured during exercise using magnetic resonance imaging.
Status | Recruiting |
Enrollment | 45 |
Est. completion date | June 30, 2025 |
Est. primary completion date | June 30, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 40 Years |
Eligibility | Inclusion Criteria: - Healthy men or women between the ages of 20-40 years old - Demonstrate an exercise history of engaging in aerobic physical activity at least 3 times per week for a minimum of 30 continuous minutes - Have experience using cardiovascular exercise equipment (e.g., treadmill, elliptical, upright or recumbent bicycle, stair-stepper) Exclusion Criteria: - Outside of specified age range - Do not have experience using cardiovascular exercise equipment - Do not meet the physical activity criteria - Present with a history or evidence of hepatic, renal, hematological disease, cardiovascular disease including uncontrolled hypertension, peripheral vascular disease, stroke/neurovascular disease, and diabetes - have a body mass index =30 kg/m2 - are = 71 inches (180 cm) in height - have any contraindications to MRI - currently use or have a history of use of tobacco or illegal substances - have current and/or a history of depression or other mood related disorders (those with mild depression and/or anxiety that is controlled with medication and/or therapy will not be excluded) - vulnerable populations (e.g., pregnant women, prisoners, individuals lacking capacity to consent) - if the desired moderate/vigorous exercise intensity corresponds to > 350 watts on the stepper device |
Country | Name | City | State |
---|---|---|---|
United States | University of Wisconsin-Madison | Madison | Wisconsin |
Lead Sponsor | Collaborator |
---|---|
University of Wisconsin, Madison |
United States,
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* Note: There are 23 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cerebral Hemodynamics | The change in cross-sectional area of the cerebral arteries during exercise will be measured with MRI. | One study visit, up to 120 minutes | |
Primary | Cerebral Blood Flow | The change in intracranial blood flow during exercise will be measured with MRI. | One study visit, up to 120 minutes |
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