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Leucoaraiosis and Multimodal MRI With Fingerprinting Technique — LEUKOPRINT  

Magnetic Resonance Imaging Clinical Trial

Official title:
Longitudinal Evaluation of Leucoaraiosis Using Multimodal MRI With Fingerprinting Technique

Clinical Trial Summary

Leukoaraiosis (LA) corresponds to an alteration of the encephalic white matter, linked to chronic hypoxia. Its pathophysiology, which has been partially elucidated, is underpinned by chronic changes in the walls of small-caliber perforating arteries, leading to chronic hypoperfusion of the white matter, associated with dysfunction of the blood-brain barrier. In affected areas, this process leads to myelin rarefaction, axonal loss, perivascular alterations and the appearance of cavitation zones. Its existence is mainly linked to the presence of vascular risk factors, most notably arterial hypertension. MR fingerprinting is an innovative Magnetic resonance Imaging (MRI) technique allowing to obtain a multiparametric MRI sequence in a non-invasively way and in a single acquisition, generating not only multiple contrasts, but also absolute longitudinal relaxation time (T1) and transverse relaxation time (T2) mappings (T1 and T2 mapping). However, the prognostic role of these T2 values, in terms of ischemic, hemorrhagic and cognitive risk, has never been studied. The objective of this study is to study and compare changes in T1 and T2 values of White Matter Hyperintensities (WMH) and Normal Appearing White Matter (NAWM) in subjects with LA.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06181981
Study type Observational
Source Lille Catholic University
Contact Marie Paule LEBITASY, MD
Phone 00 33 3 20 22 57 41
Email Lebitasy.Marie-Paule@ghicl.net
Status Recruiting
Phase
Start date November 14, 2022
Completion date November 30, 2025
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