Feasibility of Regional Lung Ventilation Imaging Using 3T MR Imaging With

Status Completed

Clinical Trial Summary

Structural lung and airway alterations in CF lead to focal or heterogeneous abnormalities in regional lung ventilation. The quantitative assessment of structural and functional alterations in the lung is of great importance for the phenotyping and follow-up of CF patients. The goal of this study is to assess the feasibility of measuring the changes in proton density in the lung parenchyma with inflation and deflation during the respiratory cycle, using ultrashort echo time (UTE) pulse sequence MRI, in healthy adult volunteers.

Clinical Trial Description

Cystic fibrosis (CF) is the most common severe autosomal recessive genetic disease in Caucasians. severe structural alterations in the airways and parenchyma, such as bronchiectasis, mucus plugging, air trapping and infiltrations. These in turn result in focal or heterogeneous abnormalities in regional lung ventilation. End-stage lung disease remains the main cause of morbidity and mortality in CF patients. Currently, new targeted CFTR correctors and potentiators are under trial. The quantitative assessment of structural and functional alterations in the lung is of great importance for the phenotyping and follow-up of CF patients, and for the assessment of targeted therapeutic interventions. Computed tomography (CT) is considered as the technology of choice for lung imaging in CF. However, CT requires exposure to significant ionizing radiation, which is a major concern in the pediatric population because children are more radiosensitive than adults and there is an increased risk of radiation-induced cancer from the cumulative dose related to repeated CT investigations. Recent improvements in magnetic resonance imaging (MRI) technology offer a non-ionizing alternative to CT for imaging the lung parenchyma. The goal of this study is to assess the feasibility of measuring the changes in proton density in the lung parenchyma with inflation and deflation during the respiratory cycle, using ultrashort echo time (UTE) pulse sequence MRI, in healthy adult volunteers. If the regional changes in proton density in the lung parenchyma during the respiratory cycle prove to be measurable in healthy volunteers, then MRI can be used to quantify regional lung ventilation. This would offer a unique non-invasive, radiation- and contrast media-free alternative to CT for phenotyping and follow-up of CF patients. ;

Study Design

Related Conditions & MeSH terms

Magnetic Resonance Imaging

Clinical Trial Details

NCT number	NCT02786056
Study type	Interventional
Source	Centre Hospitalier Universitaire, Amiens
Contact
Status	Completed
Phase	N/A
Start date	July 2015
Completion date	March 2019

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03785171` - Predicative Value of Multimodal MRI in Moyamoya Disease
Not yet recruiting	`NCT03726788` - Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis	Phase 2
Active, not recruiting	`NCT01956409` - Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis	Phase 4
Completed	`NCT01660841` - Safety and Efficacy of Gadobutrol 1.0 Molar in Japanese Subjects for CNS Imaging	Phase 3
Recruiting	`NCT03635619` - The Application of 3T MRI in Esophageal Cancer
Recruiting	`NCT03658343` - T2* MRI Analysis for Sarcoma	N/A
Recruiting	`NCT04555642` - Early Diagnosis of Therapy-associated Cardiotoxicity Basing on Multi-tracer Multimodality PET/MRI
Active, not recruiting	`NCT03441867` - Neuroimaging Biomarker for Seizures	N/A
Recruiting	`NCT04850001` - Cognitive Decline in Asymptomatic Intracranial Stenosis Patients: A 1-Year Follow-Up Study
Not yet recruiting	`NCT05816213` - Point-of-care Low-field MRI in Acute Stroke
Active, not recruiting	`NCT05498623` - MR Fingerprinting for Diagnostic of Prostate Cancer
Recruiting	`NCT04257747` - Qualitative and Quantitative Evaluation of Vascular Flows of Radial, Ulnar and Interdigital Arterial Trees Under Normal and Pathological Conditions by 3 Tesla MRI	N/A
Recruiting	`NCT04996615` - Artificial Intelligence Analysis for Magnetic Resonance Imaging in Screening Breast Cancer in High-risk Women
Recruiting	`NCT05889117` - Brain Stimulation for Concussion	N/A
Completed	`NCT02540967` - Drug Use Investigation of Gadovist.
Completed	`NCT05103189` - 4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension	N/A
Completed	`NCT02567318` - Is the Volume of the Caudate Nuclei Associated With Area of Secondary Hyperalgesia?	N/A
Recruiting	`NCT02834585` - Magnetic Resonance Imaging or Ultrasound in Soft Tissue Tumors (MUSTT)	N/A
Active, not recruiting	`NCT02446665` - Disease Status in Primary Sclerosing Cholangitis by Elastography	N/A
Completed	`NCT01721785` - Diagnostic Value of Novel MR Imaging Techniques for the Primary Staging and Restaging of Rectal Cancer	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Feasibility of Regional Lung Ventilation Imaging Using 3T MR Imaging With Ultrashort Echo Time (UTE) Pulse Sequences — PULMOREM

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms