Preoperative Ionized Magnesium Assessment

Status Completed

Clinical Trial Summary

The reported incidence of hypomagnesemia is approximately 2% in the general population. Hypomagnesemia is a common problem, occurring in nearly 10%of general hospitalized patients and 17% of hospitalized cancer patients. A higher incidence, up to 60% to 65%, has been found among intensive care unit patients. Hypomagnesemia can potentially cause fatal complications including ventricular arrhythmia, coronary artery spasm, and sudden death. It also associates with increased mortality and prolonged hospitalization. Magnesium exists in three different forms in the body. In serum, 5-14% of the magnesium is reported to be complexed with anions such as phosphate, bicarbonate, and citrate, 19-33% is reported to be protein-bound (mainly to albumin), and 55-67% is found in the free ionized fraction. Because the amount of bound or complexed Mg can vary significantly, especially in illness, the ionized magnesium can vary in an unpredictable way. Conventional laboratory testing typically only measures total serum magnesium, which is often not reflective of ionized magnesium. Unlike ionized calcium, which is commonly measured and is also readily calculated from the total calcium and albumin levels, ionized magnesium is neither commonly measured nor easily calculated. One study reported that the level of ionized magnesium cannot be predicted by analysis of total magnesium and that the levels of ionized magnesium vary upon different pathophysiological conditions and between individuals. Furthermore, measurement of ionized magnesium in serum might be of great impact in patients for whom magnesium status is required, and the correlation of ionized magnesium and total magnesium is weak in patients for whom magnesium status is required as a whole, and this is the reason why the ionized magnesium should be measured directly. To date, most of the clinical studies were evaluate the effect of hypomagnesemia on the outcome after surgery using the levels of total serum magnesium. However, the portion of extracellular magnesium that is physiologically active is in the various process is ionized magnesium. So, it is important to evaluate the level of ionized magnesium in surgical patients to predict the outcomes after surgery. Unfortunately, clinical trial regarding the effect of the concentrations of ionized magnesium on the surgical patients is limited.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Magnesium Deficiency

Clinical Trial Details

NCT number	NCT04972344
Study type	Observational
Source	Seoul National University Bundang Hospital
Contact
Status	Completed
Phase
Start date	July 27, 2021
Completion date	April 11, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04130620` - Validation of the Magnesium Muscle Stretch Test
Completed	`NCT01593501` - How Does Magnesium Status Influence Calcium Homeostasis?	Phase 4
Recruiting	`NCT04942119` - Impact of Long-term Serum Magnesium and Potassium Levels Optimization and Multifactorial Adherence Intervention on the Progression of Diabetic Kidney Disease.	N/A
Recruiting	`NCT05149820` - Point of Care RandOmisation Systems for Performing Embedded Comparative Effectiveness Trials Of Routine Treatments	Phase 4
Completed	`NCT02032186` - A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy	Phase 3
Completed	`NCT04216836` - One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running	N/A
Completed	`NCT03353636` - Bioavailability of Magnesium Supplements	N/A
Completed	`NCT02719925` - Mineral Water Rich in Magnesium and Perceived Stress in Healthy Consumers	N/A
Completed	`NCT05630339` - Magnesium and Vitamin D Combination for Post-COVID Syndrome	N/A
Completed	`NCT03554668` - Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study)
Recruiting	`NCT05271838` - Protein and Magnesium in Ulcerative Colitis	N/A
Completed	`NCT03134417` - Magnesium and Vitamin D Supplementation and Cardiometabolic Outcomes	N/A
Active, not recruiting	`NCT02674789` - Ionized Magnesium in Athletes	N/A
Completed	`NCT03466528` - Alcohol: Thiamine and or Magnesium 1	Phase 2/Phase 3
Recruiting	`NCT03840226` - The Impact of Magnesium on Exercise Tolerance, Quality of Life and Clinical Outcomes in Chronic Heart Failure Patients	Phase 3
Terminated	`NCT03471481` - Magnesium as a Mediator of Bone and Vitamin D Metabolism in Patients on Antiepileptic Drug Therapy

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.