Maculopathy Clinical Trial
The maculopathy induced by the retinal toxicity of the synthetic antimalarials must be
detected at the infra-clinical state, when it can still be reversible. Identifying early
retinal anatomical changes has always represented (a challenge for medical interns,
dermatologists, rheumatologists, and ophthalmologists). Currently, the gold-standard for its
screening and its diagnostic is the multifocal electroretinogram (mfERG), however it is a
long and tedious exam, offered by only few medical centers. It is recommended to find a
simple non-invasive alternative, on a commonly used equipment. The study of the ellipsoid
(junction line between, the external and internal photoreceptor segments) using optical
coherence tomography (OCT-SD) "en face" enables us, to obtain a panoramic viewing of the
state of the photoreceptor layer, and to detect any modification, even subtle, within this
layer. The OCT-SD "en face" can be easily done by any ophthalmologist who owns one.
The proportion of "en face" OCT-SD showing suggestive retinal damage and patients who present
retinal damage in relation with synthetic antimalarial treatments and diagnosed by mfERG is
considered in this study.
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