Macular Holes Clinical Trial
Official title:
Human Amniotic Membrane Plug for Large Macular Holes
This is a prospective, interventional, consecutive case series conducted in Alexandria university. The aim of the study is to evaluate the therapeutic efficacy of human amniotic membrane in promoting closure of large macular holes.
This is a prospective, interventional, consecutive case series conducted in Alexandria
university. The aim of the study is to evaluate the therapeutic efficacy of human amniotic
membrane in promoting closure of large macular holes.
Included participants with large macular holes will undergo complete vitrectomy is performed
with an accurate vitreal base shaving (Constellation; Alcon Surgical). A human amniotic
membrane hAM plug is taken from the hAM patch, and the final dimensions are adjusted with
vitreoretinal scissors before insertion into the vitreous. The hAM plug is rolled inside the
vitreoretinal forceps and inserted through the trocar into the vitreous. Then the human
amniotic membrane is transplanted through macular hole into the subretinal space; it is then
spread to cover the entire portion of the hole. Afterward, perfluorocarbon is injected to a
complete overfilling of the break to permit good adhesion of the hAM plug to the underlying
RPE and the overlying retina. Fluid-air exchange and an endotamponade injection is performed
at the end of surgery.
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