Learning Study: Improving Vision in Adults With Macular Degeneration

Macular Degeneration Clinical Trial

Official title:

Improving Vision in Adults With Macular Degeneration, Study 2: The Effect of Concurrent Perceptual Learning and Brain Stimulation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04762368
• Other study ID #: VSBrainStim2
• Status: Recruiting
• Phase: N/A
• Start date: February 13, 2021
• Est. completion date: December 2024

Study information

• Verified date: March 2024
• Source: University of Waterloo
• Contact: Ben Thompson, PhD
• Phone: 15198884567
• Email: ben.thompson[@]uwaterloo.ca
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to test whether a kind of brain stimulation called anodal transcranial direct current stimulation (a-tDCS) can be combined with perceptual learning to improve the ability of people with age-related macular degeneration (AMD) or juvenile macular degeneration (JMD) to read words presented to them on a computer screen better than if perceptual learning alone were used.

In addition, secondary measures of visual acuity will also be examined to determine whether brain stimulation can allow patients to resolve finer details of an image. The proposed treatment is the application of a-tDCS onto the participant's head, with brain stimulation aimed at Primary Visual Cortex toward the occipital pole, while patients undergo six separate sessions of training. The investigators will test the ability of participants to read words before the start of the training sessions (pre test) and after the completion of all training sessions (post test). This is a between-subjects design, and half of the participants will receive true stimulation, and the other half will receive sham stimulation. The difference between the pre and post tests when receiving active stimulation will be compared to the difference when receiving sham stimulation, because the sham stimulation is not expected to influence reading beyond a placebo. The aim of the study is to examine the potential of concurrent brain stimulation and perceptual learning as an effective treatment for macular degeneration that may be used in conjunction with more traditional eye-based interventions. The investigators hypothesize that the brain stimulation will enable higher performance in the reading task after and secondary measures after perceptual training due to an increase in the cortical excitability of the stimulated brain cells.

Description:

This study will be carried out in Ontario, Canada (University of Waterloo) and Hong Kong (The Hong Kong Polytechnic University). There are two conditions: Active brain stimulation + perceptual training and sham/placebo brain stimulation + perceptual training. This study uses a between-subjects design, such that half of all participants will be placed in the active stimulation group and half will be placed in the sham group.

Participants will be recruited from university-affiliated clinics and local clinical practices. Following full informed consent, participants will complete baseline testing and clinical testing to confirm that they meet eligibility criteria including: a diagnosis of macular degeneration without any additional eye disease, impaired vision but with enough visual acuity that the computer monitor can still present readable word, and no contraindications for brain stimulation interventions. Eligible participants will then be randomized to either receiving the active stimulation during perceptual training or the placebo stimulation during perceptual training.

The primary outcome measure is verbal reading accuracy for sentences presented on a computer screen following a Rapid Serial Visual Presentation (RSVP) task in which a single word is presented on the screen at a time. Participants will freely observe the words and will indicate the words on the screen verbally. The secondary outcome measures are contrast sensitivity and crowded and uncrowded visual acuity as measured by Freiburg Visual Acuity & Contrast Test (FrACT) using the Landolt C stimulus. The "C"'s gap will be oriented randomly, and the participant will indicate the orientation of the stimulus. Crowded visual acuity will be assessed with Landolt C surrounded by a solid ring, while uncrowded visual acuity will be assessed with the Landolt C alone. The Test of contrast sensitivity will measure the amount of contrast required relative to the background to identify the orientation of the "C". The Hong Kong Polytechnic University has an additional set of secondary outcome measures of temporal and spatial visual span. Temporal visual span will be assessed using Chinese trigrams presented horizontally or vertically at the centre for a range of presentation times. Spatial visual span will be assessed using Chinese trigrams presented horizontally or vertically at different character positions for a fixed presentation time. Participants will be asked to recognize all three characters in a correct order.

The study consists of 9 sessions plus 1 additional session particularly for Hong Kong Polytechnic University

Session 0: This session only applies for The Hong Kong Polytechnic university, that horizontal and vertical temporal and spatial visual span will be collected.

Session 1: The first session will include the clinical evaluation. In addition, the pre tests of all outcome measures will be collected (RSVP performance, crowded and uncrowded visual acuity, contrast sensitivity).

Sessions 2-7: Brain stimulation sessions. Participants will undergo roughly 1 hour of perceptual training, performing the RSVP task. The first 25 minutes of this training will include either sham or active brain stimulation. A given participant will receive the same kind of stimulation for all 6 training sessions.

Session 8: No brain stimulation will occur. Post test outcome measures will be collected (RSVP performance, crowded and uncrowded visual acuity, contrast sensitivity, horizontal and vertical temporal and spatial visual span).

Session 9: 30 day follow up. 30 days after the final training session, participants will again perform the outcome measures without brain stimulation to determine the long term benefit of the perceptual training + brain stimulation.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: December 2024
• Est. primary completion date: December 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Diagnosis of AMD (age 60+) or JMD (current age 18+).

2. Visual acuity (VA); between 6/9-6/96 in the better eye

3. Best-corrected near visual acuity of 4.0M at 40 cm or better in the better eye

4. Stable vision in previous 3 months (patient report)

5. Central vision loss

Exclusion Criteria:

1. Diagnosed dementia.

2. Not fluent in reading English (Waterloo) or Chinese characters (Hong Kong).

3. Any ocular surgery (including anti-vegF injections) within the duration of the study, except for: A. Chronic and continuous injections for at least 1 year. B. Injections stopped at least 2 months before participation. C. Injections in the untested eye

4. Ocular pathology other than JMD or AMD that can significantly reduce central vision. Example: mild cataract of grade 2 or below is acceptable

5. Severe hearing impairment.

6. Contraindications for brain stimulation

Related Conditions & MeSH terms

• Macular Degeneration

Intervention

Device:
• Active anodal tDCS
a weak electric current is applied to the head through electrodes to affect the cortical excitability of the targeted cells in the brain.
• Sham anodal tDCS
The tDCS machine will be used as in active stimulation, except the electrical current will not be applied.

Locations

Country	Name	City	State
Canada	University of Waterloo	Waterloo	Ontario
Hong Kong	The Hong Kong Polytechnic University	Hung Hom	Kowloon

Sponsors (2)

Lead Sponsor	Collaborator
University of Waterloo	The Hong Kong Polytechnic University

Countries where clinical trial is conducted

Canada,  Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Rapid Serial Visual Presentation (RSVP) Reading performance before and right after training.	Behavioral Measure - Participants will verbally read words presented on a computer. A variety of speeds and sizes will be presented, so that an accurate measure of the maximum reading speed, and the smallest text size readable at the maximum reading speed can be calculated. The maximum reading speed and smallest text size will be measured before and after training. The outcome measures are the change in these reading measurements from pre test to post test.	The pre test and post test will take roughly 1 hour to complete, and they will be roughly 4-7 weeks apart.
Primary	Change in Rapid Serial Visual Presentation (RSVP) Reading performance 30 days after training	Behavioral Measure - Participants will verbally read words presented on a computer. A variety of speeds and sizes will be presented, so that an accurate measure of the maximum reading speed, and the smallest text size readable at the maximum reading speed can be calculated. The maximum reading speed and smallest text size will be measured before and after training. The outcome measures are the change in these reading measurements from pre test to the 30 day follow up.	The test will take roughly 1 hour to complete, and they will be roughly 7-10 weeks apart.
Secondary	Change in Uncrowded Visual Acuity before and just after training	Visual acuity as measured by participants indicating the orientation of the gap present in a Landolt C stimulus using the freely available FrACT software https://michaelbach.de/fract/index.html . The outcome measure is the change in performance from pre test to the post test	The pre test and post test will take roughly 5 minutes to complete, and they will be roughly 4-7 weeks apart.
Secondary	Change in Uncrowded Visual Acuity before and 30 days after training	Visual acuity as measured by participants indicating the orientation of the gap present in a Landolt C stimulus using the freely available FrACT software https://michaelbach.de/fract/index.html . The outcome measure is the change in performance from pre test to the 30 day follow up.	The pre test and post test will take roughly 5 minutes to complete, and they will be roughly 7 to 10 weeks apart.
Secondary	Change in Crowded Visual Acuity before and just after training	Visual acuity as measured by participants indicating the orientation of the gap present in a Crowded (Ring) Landolt C stimulus using the freely available FrACT software https://michaelbach.de/fract/index.html . The outcome measure is the change in performance from pre test to post test.	The tests will take roughly 5 minutes to complete, and they will be roughly 4 - 7 weeks apart.
Secondary	Change in Crowded Visual Acuity before and 30 days after training	Visual acuity as measured by participants indicating the orientation of the gap present in a Crowded (Ring) Landolt C stimulus using the freely available FrACT software https://michaelbach.de/fract/index.html . The outcome measure is the change in performance from pre test to the 30 day follow up.	The tests will take roughly 5 minutes to complete, and they will be roughly 7 - 10 weeks apart.
Secondary	Change in Contrast Sensitivity before and just after training	Contrast sensitivity as measured by participants indicating the orientation of the gap present in a Landolt C stimulus using the freely available FrACT software https://michaelbach.de/fract/index.html . The outcome measure is the change in performance from pre test to the post test.	The tests will take roughly 5 minutes to complete, and they will be roughly 4 - 7 weeks apart.
Secondary	Change in Contrast Sensitivity before and 30 days after training	Contrast sensitivity as measured by participants indicating the orientation of the gap present in a Landolt C stimulus using the freely available FrACT software https://michaelbach.de/fract/index.html . The outcome measure is the change in performance from pre test to the 30 day follow up.	The tests will take roughly 5 minutes to complete, and they will be roughly 7-10 weeks apart.
Secondary	Change in Temporal Visual Span before and just after training	Three unrelated Chinese characters will appear at the centre of a monitor for a range of exposure times. Participants will be asked to recognize all three characters in a correct order. Both horizontal and vertical presentation will be assessed. The outcome measures are the changes in time for recognizing the characters from pre test to the post test.	The test will take roughly 1.5 hours to complete, and they will be roughly 5-8 weeks apart
Secondary	Change in Spatial Visual Span before and just after training	Three unrelated Chinese character will appear at different character positions for a fixed exposure time, while participants will be asked to keep fixation at the centre but recognize all three characters in a correct order. Both horizontal and vertical presentation will be assessed. The outcome measures are the changes in the size of the spatial visual span from pre test to the post.	The test will take roughly 1.5 hours to complete, and they will be roughly 5-8 weeks apart.