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NCT00089830 Clinical Trial

A Safety and Efficacy Study of MSI-1256F (Squalamine Lactate) To Treat "Wet" Age-Related Macular Degeneration

Macular Degeneration Clinical Trial

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT00089830
Other study ID # MSI-1256F-209
Secondary ID
Status Terminated
Phase Phase 2
First received August 16, 2004
Last updated November 27, 2007
Start date August 2004
Est. completion date May 2007

Study information
Verified date November 2007
Source Genaera Corporation
Contact n/a
Is FDA regulated No
Health authority United States: Food and Drug Administration
Study type Interventional

Clinical Trial Summary

Age-Related Macular Degeneration (AMD) is a degenerative eye disease of the retina that causes a progressive loss of central vision. AMD is the leading cause of legal blindness among adults age 50 or older in the Western world. AMD presents in two different types - "dry" and the more severe "wet" form. Wet AMD is caused by the growth of abnormal blood vessels in the macula. Squalamine lactate is an investigational drug that may prevent the growth of these abnormal blood vessels. This study will test the safety and efficacy of Squalamine in the treatment of AMD.

Recruitment information / eligibility
Status Terminated
Enrollment 120
Est. completion date May 2007
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 50 Years and older
Eligibility Inclusion Criteria:

- Patients with a diagnosis of "wet" age-related macular degeneration

Exclusion Criteria:

- Prior treatment of "wet" age-related macular degeneration in the affected eye in the past 3 months

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• MSI-1256F (Squalamine Lactate)

Locations
Country Name City State
United States Genaera Corporation Plymouth Meeting Pennsylvania

Sponsors (1)
Lead Sponsor Collaborator
Genaera Corporation

Country where clinical trial is conducted

United States, 

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