Lymphomas Clinical Trial
Official title:
A Phase I, Open-Label, Multiple Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of RRx-001 in Subjects With Advanced Solid Tumors or Lymphomas For Which There Are No Currently Accepted Curative Therapies
The purpose of this study is to evaluate the safety and pharmacokinetic profile of RRx-001 for injection in subjects with advanced solid tumors or lymphomas for which there are no currently accepted curative therapies. This study will also conduct an exploratory evaluation of objective tumor response using CT or MRI.
The DINAMIC (DINitroazetidines As Medications In Cancer) trial represents a provascular approach to temporarily change tumor blood flow and oxygenation. Blood supply to most tumors is poor, causing parts of tumors to have a low oxygen content which promotes aggressiveness and metastasis. The DINAMIC trial uses specific imaging techniques (including ultrasound), biopsy, and breath analysis to provide an early assessment of therapeutic activity. ;
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02140736 -
Epoetin Alfa Biosimilar in the Management of Chemotherapy-Induced Symptomatic Anemia in Haematology and Oncology
|
||
Completed |
NCT00725634 -
A Phase 1 Dose-Escalation Study in Advanced Solid Tumors, Lymphomas or Multiple Myeloma
|
Phase 1 | |
Completed |
NCT00947739 -
Phase I and Pharmacology Study of Camptothecin-20-O-Propionate Hydrate (CZ48) in Patients With Solid Tumors or Lymphoma
|
Phase 1 | |
Completed |
NCT00222443 -
Pilot Study Combining Temozolomide, Oncovin, Camptosar and Oral Antibiotic in Children and Adolescents With Recurrent Malignancy
|
Phase 1 | |
Recruiting |
NCT02211755 -
Trial of the Combination of Bortezomib and Clofarabine in Adults With Relapsed Solid Tumors
|
Phase 1 | |
Completed |
NCT02048488 -
A Phase I/IIa Open-Label, Dose Escalation and Cohort Expansion Trial of Oral TSR-011 in Patients With Advanced Solid Tumors and Lymphomas
|
Phase 1/Phase 2 | |
Recruiting |
NCT06148220 -
A Study of the Clinical Application of [18F]RCCB6 and [68Ga]Ga-NOTA-RCCB6 PET/CT Imaging in the Diagnosis of CD70-expressing Multiple Tumors
|
N/A | |
Completed |
NCT01031641 -
Refinement of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) Via Cognitive Interviewing and Usability Testing
|
||
Withdrawn |
NCT02786485 -
Study of Matched Unrelated Donor T Cell Infusion for Hematologic Malignancies After Allo-HSCT
|
Phase 1 | |
Completed |
NCT01387841 -
Effect of Yoga in Reducing Chemotherapy Induced Nausea and Vomiting
|
Phase 2 | |
Completed |
NCT00396864 -
Phase 1 Clinical Trial of NPI-0052 in Patients With Advanced Solid Tumor Malignancies or Refractory Lymphoma
|
Phase 1 | |
Terminated |
NCT00023166 -
Phase I Study of PEG-Paclitaxel In Patients With Advanced Solid Tumors & Lymphomas
|
Phase 1 | |
Recruiting |
NCT04417803 -
Interest of Individual Biomarkers From the Identification of Tumor Genotype by High-throughput Molecular Techniques
|
N/A | |
Recruiting |
NCT05775406 -
Safety and Clinical Activity of KT-253 in Adult Patients With High Grade Myeloid Malignancies, Acute Lymphocytic Leukemia, Lymphoma, Solid Tumors
|
Phase 1 | |
Recruiting |
NCT02274584 -
CAR T Cells Targeting CD30 Positive Lymphomas (4SCAR30273)
|
Phase 1/Phase 2 | |
Recruiting |
NCT01836822 -
Bronchoscopic Sampling Techniques in Sarcoidosis
|
N/A | |
Completed |
NCT02902237 -
tTF-NGR Phase I Study
|
Phase 1 | |
Completed |
NCT02578316 -
A Study to Determine the Metabolism and Elimination of 14C-E7080 in Patients With Advanced Solid Tumors or Lymphomas, Who Are Unsuitable For, or Have Failed, Existing Therapies.
|
Phase 1 | |
Recruiting |
NCT00900198 -
Collection of Tissue Samples for Cancer Research
|
||
Completed |
NCT02740270 -
Phase I/Ib Study of GWN323 Alone and in Combination With PDR001 in Patients With Advanced Malignancies and Lymphomas
|
Phase 1 |