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Clinical Trial Summary

This is the first-in-human study with BYON4228, a humanized monoclonal antibody (mAb) directed against SIRPα.


Clinical Trial Description

This study includes a dose escalation part (Part 1) in which the MTD and dose regimen for expansion (RDE) will be determined, and an expansion part (Part 2) to evaluate efficacy and safety in specific patient cohorts. BYON4228 is a humanized IgG1 mAb directed against SIRPα. BYON4228 binds SIRPα expressed on innate immune cells, especially monocytes, macrophages and neutrophils. BYON4228 blocks binding of SIRPα to CD47 and inhibits signaling through the CD47-SIRPα axis. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05737628
Study type Interventional
Source Byondis B.V.
Contact Willem Klaassen
Phone +31 (0)24 679 5100
Email clinicaltrials@byondis.com
Status Recruiting
Phase Phase 1
Start date March 4, 2024
Completion date December 1, 2025

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