Lymphoma Clinical Trial
Official title:
Serial Viral Load Changes and Hepatotoxicity in Lymphoma Patients With Hepatitis C Antibody After Chemotherapy Treatment: A Prospective Multicenter Observational Study and Long-term Retrospective Analysis
In last few years, most researches about hepatic complication after chemotherapy focused on
hepatitis B virus (HBV). With adequate prophylaxis and monitor, HBV-related hepatitis flares
can be prevented. In contrast, cancer patients with hepatitis C virus (HCV) infection are
traditionally considered as relative safe to receive chemotherapy. However, two large
retrospective studies recently showed that severe hepatitis could develop in 14-27% lymphoma
patients with chronic HCV infection, including 3-4% hepatic failure. The risk factors to
predict severe hepatitis are pre-treatment elevated ALT level and liver cirrhosis. Due to
the lack of prospective studies, the dynamic changes of serum HCV RNA levels and the
association of hepatitis are still unclear.
Some epidemiologic studies demonstrated an association between HCV infection and B-cell
lymphoma. Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma and several
reports showed higher prevalence of HCV infection among DLBCL patients than the controls.
HCV infected DLBCL patients are reported to have distinct clinical characteristics, such as
older, more with elevated LDH levels, and more with extra-nodal involvement. Regarding the
impact of HCV infection on prognosis, the results are conflicting. Taiwan is an endemic area
of HCV but there are limited reports addressing the clinical characteristics and prognosis
in this unique population.
Therefore, the investigators initiate a prospective, multi-center observational study to
clarify the dynamic association between serum HCV RNA levels and hepatitis in HCV-infected
lymphoma patients treated with chemotherapy.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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