Lymphoma Clinical Trial
Official title:
Development of a Biomarker Directed Strategy to Ameliorate Common Toxicities From Conventional Chemotherapy
Side effects from chemotherapy can be severe in some patients leading to admission to
hospital, a worse quality of life and delays in subsequent doses of chemotherapy. A blood
test that could predict patients who will go on to develop severe side effects could be
useful and might allow early intervention with medicines to reduce the severity of the
symptoms and prevent admission to hospital.
This study will collect blood samples from patients with lymphoma or sarcoma who are
receiving chemotherapy (with an expected admission rate for neutropenic sepsis, one of the
side effects that most commonly results in hospital admission, of less than 20%). It will
assess whether changes in blood proteins ("biomarkers") taken 2 days after the 1st
chemotherapy can predict subsequent severe side effects throughout the 4 months of
chemotherapy. In addition the investigators will collect data on quality of life and contact
with medical professionals to assess the costs of chemotherapy toxicity to both the patient
and health service. This will allow us in the future to model the cost effectiveness of
using biomarkers in this manner to try and reduce chemotherapy toxicity.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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