Lymphoma Clinical Trial
Official title:
The Influence of KIR and HLA Genotype on the Response to Rituximab Immunotherapy in Patients With Follicular Lymphoma
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors predict how well patients will respond to treatment.
PURPOSE: This research study is studying DNA isolated from blood samples to see how well it
influences response to rituximab in patients with follicular lymphoma treated on clinical
trial ECOG-E4402.
OBJECTIVES:
- To test the influence of killer immunoglobulin-like receptor (KIR) and human lymphocyte
antigen (HLA) genotype on response to anti-CD20 antibody lymphoma immunotherapy.
OUTLINE: DNA samples are analyzed for killer immunoglobulin-like receptor (KIR) and human
lymphocyte antigen (HLA) genotyping with sequence-specific primers (SSP) by real-time PCR.
KIR and HLA typing are analyzed according to KIR-HLA matched vs mismatched, KIR B haplotype
content, and the number of inhibitory KIR-HLA pairs. Results are then correlated to each
patient's overall response and duration of response to rituximab.
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