Lymphoma Clinical Trial
Official title:
Quantification of HIV-1 Reservoirs in HIV-Positive Persons Receiving Response-Adapted Therapy for Stage III-IV Hodgkin Lymphoma: A Companion Protocol to SWOG Protocol S0816 (AMC-073)
RATIONALE: Studying samples of blood in the laboratory from patients undergoing treatment
with HIV infection and Hodgkin lymphoma may help doctors learn more about the effects of
therapy on HIV.
PURPOSE: This research study is studying biomarkers in blood samples from patients with HIV
infection and stage III or stage IV Hodgkin lymphoma undergoing chemotherapy.
OBJECTIVES:
Primary
- To quantify HIV-1 persistence in prospectively collected samples from patients on
suppressive antiretroviral therapy undergoing chemotherapy for Hodgkin lymphoma.
OUTLINE: This is a multicenter study.
Blood samples are collected before, during, and after treatment for lymphoma for HIV-1 RNA
levels using standard and single copy assays and HIV-1 DNA quantification (peripheral blood
mononuclear cells).
After completion of treatment, patients are followed up periodically for up to 2 years.
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