Lymphoma Clinical Trial
Official title:
Gene Expression Profiling Using Paraffin-embedded Tissues and the Nuclease Protection Assay in Diffuse Large B-cell Lymphoma (DLBCL) Treated With CHOP or R-CHOP: An ECOG and SWOG Correlative Study of E4494
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors identify and learn more about biomarkers related to cancer. It may also help doctors
predict how well patients will respond to treatment.
PURPOSE: This research study is studying biomarkers in patients with diffuse large B-cell
lymphoma treated with combination chemotherapy with or without rituximab.
OBJECTIVES:
- To identify genes predictive of clinical outcome (failure-free survival and overall
survival) among patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP
induction on ECOG-E4494 using the nuclease protection assay for measuring gene
expression in paraffin-embedded tissue.
- To identify genes that change their prognostic profile with the addition of rituximab
to CHOP chemotherapy.
OUTLINE: This is a multicenter study.
Unstained formalin-fixed, paraffin-embedded samples are analyzed for gene expression via
nuclease protection assay.
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