Lymphoma Clinical Trial
Official title:
Detection of Donor-Derived DNA in Semen Samples Among Recipients of Allogeneic Hematopoietic Stem-Cell Transplants
RATIONALE: Studying samples of semen from cancer survivors in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This phase I research study is looking at the presence of donor-derived DNA in
semen samples form cancer survivors who underwent donor stem cell transplant.
OBJECTIVES:
- To examine semen samples from male survivors of allogeneic hematopoietic stem cell
transplantation for the presence of donor-derived DNA.
OUTLINE: Semen samples are collected and assessed by flow cytometry and PCR. DNA samples are
compared to previously analyzed DNA extracted from survivor and donor. Samples are also
analyzed for sperm concentration, motility, morphology, and viability.
;
Observational Model: Case-Only, Time Perspective: Prospective
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