Lymphoma Clinical Trial
Official title:
Identification of Biomarkers in Follicular Lymphoma
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors identify and learn more about biomarkers related to cancer. It may also help doctors
predict how patients respond to treatment.
PURPOSE: This laboratory study is looking at biomarkers in patients with stage III or stage
IV follicular lymphoma treated on clinical trial E-1496.
OBJECTIVES:
- Correlate gene expression profiles with progression-free survival (PFS) of patients with
stage III or IV follicular lymphoma treated with cyclophosphamide, vincristine, and
prednisone with or without rituximab on clinical trial E-1496.
- Determine if immunoglobulin Fc-gamma receptor polymorphisms are predictive of PFS in
these patients.
- Assess the significance of the microenvironment by constructing tissue microarrays of
follicular lymphoma and immunostaining with relevant biomarkers.
- Correlate relevant biomarkers with clinical features, response, and PFS.
OUTLINE: This is a multicenter study.
Tissue samples are analyzed by gene expression profiling, microarrays to predict gene
expression, immunohistochemistry, and immunoglobulin Fc-gamma receptor polymorphism analysis
for biological markers.
PROJECTED ACCRUAL: A total of 175 samples will be accrued for this study.
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