Lymphoma Clinical Trial
Official title:
Analysis of E4494 Tissues to Determine the Prognostic Significance of Biomarkers in Diffuse Large B Cell Lymphoma (DLBCL) Treated With Standard Chemotherapy (CHOP) Plus Rituximab ®)1
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors identify and learn more about biomarkers related to cancer. It may also help doctors
understand how patients respond to treatment.
PURPOSE: This laboratory study is looking at biomarkers using tissue samples from older
patients with diffuse large B-cell lymphoma treated with combination chemotherapy with or
without rituximab on clinical trial ECOG-E4494.
OBJECTIVES:
- To construct tissue microarrays (TMA) using tissue samples from older patients with
diffuse large B-cell lymphoma treated with standard CHOP chemotherapy
(cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab
on clinical trial ECOG-E4494.
- To allow this TMA resource to be included in a large international effort (the
Lunenburg Lymphoma Biomarker Consortium [LLBC]), partnering with several other similar
randomized trials (EORTC, HOVON, GELA, MINT) in order to properly power and bring
standardization to the study of biomarkers in lymphoma.
- To evaluate the clinical impact and prognostic importance of a number of biomarkers,
including Bcl-2, Bcl-6, CD10, FOXP1, MUM1, Ki-67, CD5, and HLA-Dr.
- To determine the prognostic impact of clinical International Prognostic Index (IPI)
variables in a large international study.
- To determine the relationship between different biomarkers and clinical predictors.
- To establish the TMA (using tissue samples from patients treated on clinical trial
ECOG-E4494) as a resource for future ECOG-driven studies and for validation of novel
biomarkers as they become recognized and available.
OUTLINE: Patients are stratified according to prior treatment (CHOP chemotherapy
[cyclophosphamide, doxorubicin, vincristine, and prednisone] or CHOP-like chemotherapy vs
CHOP chemotherapy with or without rituximab).
Tissue microarrays will be constructed using tissue samples previously collected from
patients treated on clinical trial ECOG-E4494. Tissue microarrays will be used for biomarker
studies.
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