Lymphoma Clinical Trial
Official title:
Assessment of MUM1 Expression, Lymphoma-Associated Macrophages, and Regulatory T-Cells in Follicular Lymphoma: Prognostic Markers in SWOG S8809 and S9800/S9911 Trials Representing Pre-and Post-Monoclonal Antibody Therapy Protocols
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors identify and learn more about biomarkers related to cancer. It may also help doctors
predict how patients respond to treatment.
PURPOSE: This laboratory study is examining biological markers in patients with follicular
lymphoma treated on clinical trial SWOG-8809, SWOG-9800, or SWOG-9911.
OBJECTIVES:
- Determine the prognostic significance of MUM-1, lymphoma-associated macrophages, and
regulatory T cells in patients with follicular lymphoma treated on clinical trials
SWOG-8809, SWOG-9800, or SWOG-9911 representing pre- and post-monoclonal antibody
therapy protocols.
- Determine whether these factors have similar prognostic significance in patients
treated with chemotherapy alone vs chemotherapy and monoclonal antibody therapy on
these clinical trials.
OUTLINE: This is a multicenter study.
Previously collected tissue samples from patients are analyzed by immunohistochemistry, gene
expression profiling, and quantitative analysis for MUM1 expression, lymphoma-associated
macrophages, FOXP3-positive regulatory T cells, CD68, and CD163.
PROJECTED ACCRUAL: A total of 318 samples will be accrued for this study.
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